Table 4 |
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|
Stratification analyses for associations between rs3731055 genotypes and risk of lung cancer by selected variables |
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|
XPC rs3731055 genotype |
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|
|
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|
Variables |
Case (n = 967) |
Control (n = 985) |
Adjusted OR (95% CI) |
|||
|
|
|
|
||||
|
GG |
AG/AA |
GG |
AG/AA |
GG |
AG/AA |
|
|
|
||||||
|
Total |
541 (0.56) |
426 (0.44) |
512 (0.52) |
473 (0.48) |
1.00 |
0.82 (0.68–0.99)* |
|
Age (years) |
||||||
|
≤ 60 |
282 (0.59) |
195 (0.41) |
240 (0.49) |
245 (0.51) |
1.00 |
0.65 (0.50–0.85)** |
|
> 60 |
259 (0.53) |
231 (0.47) |
272 (0.54) |
228 (0.46) |
1.00 |
1.03 (0.80–1.34) |
|
Sex |
||||||
|
Male |
420 (0.56) |
329 (0.44) |
382 (0.52) |
353 (0.48) |
1.00 |
0.82 (0.66–1.01) |
|
Female |
121 (0.55) |
97 (0.45) |
130 (0.52) |
120 (0.48) |
1.00 |
0.86 (0.59–1.24) |
|
Smoke status |
||||||
|
None-smoker |
178 (0.60) |
119 (0.40) |
251 (0.53) |
221 (0.47) |
1.00 |
0.74 (0.55–0.99)* |
|
Smoker |
363 (0.54) |
307 (0.46) |
261 (0.51) |
252 (0.49) |
1.00 |
0.90 (0.71–1.13) |
|
< 30 pack-years |
136 (0.56) |
107 (0.44) |
136 (0.52) |
127 (0.48) |
1.00 |
0.88 (0.61–1.25) |
|
≥ 30 pack-years |
227 (0.53) |
200 (0.47) |
125 (0.50) |
125 (0.50) |
1.00 |
0.91 (0.66–1.24) |
|
Family history of cancer |
||||||
|
No |
435 (0.54) |
363 (0.46) |
442 (0.52) |
416 (0.48) |
1.00 |
0.84 (0.69–1.03) |
|
Yes |
106 (0.63) |
63 (0.37) |
70 (0.55) |
57 (0.45) |
1.00 |
0.71 (0.43–1.18) |
|
|
||||||
|
a ORs were obtained from a logistic regression model with adjustment for age, sex, residential area, and family history of cancer, and smoking (pack/yr). *P < 0.05; **P < 0.01. |
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|
Bai et al. BMC Cancer 2007 7:81 doi:10.1186/1471-2407-7-81 |
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