Table 4

Stratification analyses for associations between rs3731055 genotypes and risk of lung cancer by selected variables

XPC rs3731055 genotype


Variables

Case (n = 967)

Control (n = 985)

Adjusted OR (95% CI)




GG

AG/AA

GG

AG/AA

GG

AG/AA


Total

541 (0.56)

426 (0.44)

512 (0.52)

473 (0.48)

1.00

0.82 (0.68–0.99)*

Age (years)

≤ 60

282 (0.59)

195 (0.41)

240 (0.49)

245 (0.51)

1.00

0.65 (0.50–0.85)**

> 60

259 (0.53)

231 (0.47)

272 (0.54)

228 (0.46)

1.00

1.03 (0.80–1.34)

Sex

Male

420 (0.56)

329 (0.44)

382 (0.52)

353 (0.48)

1.00

0.82 (0.66–1.01)

Female

121 (0.55)

97 (0.45)

130 (0.52)

120 (0.48)

1.00

0.86 (0.59–1.24)

Smoke status

None-smoker

178 (0.60)

119 (0.40)

251 (0.53)

221 (0.47)

1.00

0.74 (0.55–0.99)*

Smoker

363 (0.54)

307 (0.46)

261 (0.51)

252 (0.49)

1.00

0.90 (0.71–1.13)

< 30 pack-years

136 (0.56)

107 (0.44)

136 (0.52)

127 (0.48)

1.00

0.88 (0.61–1.25)

≥ 30 pack-years

227 (0.53)

200 (0.47)

125 (0.50)

125 (0.50)

1.00

0.91 (0.66–1.24)

Family history of cancer

No

435 (0.54)

363 (0.46)

442 (0.52)

416 (0.48)

1.00

0.84 (0.69–1.03)

Yes

106 (0.63)

63 (0.37)

70 (0.55)

57 (0.45)

1.00

0.71 (0.43–1.18)


a ORs were obtained from a logistic regression model with adjustment for age, sex, residential area, and family history of cancer, and smoking (pack/yr).

*P < 0.05; **P < 0.01.

Bai et al. BMC Cancer 2007 7:81   doi:10.1186/1471-2407-7-81

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