Figure 1.

Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model. Effects of liarozole alone and in combination with tamoxifen on tumor burden of MNU-induced rat mammary carcinoma in cycling female Sprague-Dawley rats. Treatment groups: controls, liarozole 20 mg/kg (L20), liarozole 80 mg/kg (L80), liarozole 20 mg/kg in combination with tamoxifen 100 μg/kg (L20+T100), liarozole 80 mg/kg in combination with tamoxifen 100 μg/kg (L80+T100) and tamoxifen 100 μg/kg (T100).