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Open AccessHighly AccessResearch article

Serum diagnosis of diffuse large B-cell lymphomas and further identification of response to therapy using SELDI-TOF-MS and tree analysis patterning

Xing Zhang2,3 email, Bo Wang1,3 email, Xiao-shi Zhang2,3 email, Zhi-ming Li1,3 email, Zhong-zhen Guan1,3 email and Wen-qi Jiang1,3 email

1Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

2Department of Biotherapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

3State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

author email corresponding author email

BMC Cancer 2007, 7:235doi:10.1186/1471-2407-7-235

Published: 29 December 2007

Additional files

Additional file 1:

Supplemental figure 1 showing nine protein biomarkers in serum for detection of DLBCL. Mass spectra of serum samples from two different DLBCL patients (Tumor1 and Tumor2) and two nontumor control (Ctrl-1 and Ctrl-2). The average molecular mass of the nine proteins identified to be unique or overexpressed in the tumor specimens are: 2821 Da, 2954 Da, 3266 Da, 4779 Da, 5638 Da, 5707 Da, 5838 Da, 5907 Da, and 7975 Da (arrow).

Format: TIFF Size: 123KB Download file

Additional file 2:

Supplemental figure 2 showing seven serum peaks in mass pattern for diagnosis of SELDI. Mass spectra of serum samples from two different DLBCL patients (Tumor1 and Tumor2) and two nontumor control (Ctrl-1 and Ctrl-2). The average molecular mass of the four proteins identified to be unique or overexpressed in the Ctrl specimens are: 2091 Da, 3960 Da, 4872 Da, and 14133 Da; the three DLBCL-associated proteins as listed in tumor specimens: 2503 Da, 5251 Da, and 5814 Da (arrow).

Format: TIFF Size: 126KB Download file


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