Table 3 |
||||||||||||
|
Incidence of clinically relevant toxicities |
||||||||||||
|
Toxicities |
Cohort 1 |
Cohort 2 |
Cohort 3 |
Cohort 4 |
Cohort 5 |
Cohort 6 |
||||||
|
|
||||||||||||
|
Toxicity Grade |
||||||||||||
|
1/2 |
3/4 |
1/2 |
3/4 |
1/2 |
3/4 |
1/2 |
3/4 |
1/2 |
3/4 |
1/2 |
3/4 |
|
|
|
||||||||||||
|
Alkaline phosphatase elevation |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
|
Anemia |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Creatinine elevation |
1 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
Hyperkalemia |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Hypoalbuminemia |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Infection |
0 |
0 |
0 |
1* |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Insomnia |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Nausea/emesis |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
|
Neuropathy |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
|
Pruritis |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Weakness/fatigue |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
||||||||||||
|
* Right gluteal and inguinal furuncles (culture positive for mixed flora – gram positive and gram cocci as well as methicillin sensitive and resistant staph aureus. |
||||||||||||
|
Hayslip et al. BMC Cancer 2007 7:221 doi:10.1186/1471-2407-7-221 |
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