|
Odds Ratios (95% CI) of gastric cancer for SNPs in metabolic genes according to smoking status and alcohol habits |
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| Never-smokers (57 cases, 146 controls) |
Ever-smokers (50 cases, 108 controls) |
p for heterogeneity |
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|
|
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| cases/controls |
OR (95% CI) * † |
cases/controls |
OR (95% CI) |
||
|
|
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| GSTM1 null |
33/70 |
1.55 (0.83–2.90) |
26/64 |
0.70 (0.35–1.39) |
0.10 |
| GSTT1 null |
21/34 |
2.09 (1.06–4.11) |
18/23 |
2.17 (1.02–4.59) |
0.92 |
| CYP1A1*2A |
14/33 |
1.09 (0.53–2.27) |
8/23 |
0.66 (0.27–1.61) |
0.40 |
| CYP2E1*5 |
4/11 |
0.86 (0.26–2.88) |
1/9 |
0.20 (0.02–2.70) |
0.24 |
| CYP2E1*5A or *6 |
10/17 |
1.59 (0.67–3.79) |
5/10 |
0.99 (0.31–3.13) |
0.58 |
| NAT2 Slow ‡ |
34/77 |
1.39 (0.74–2.60) |
30/54 |
1.50 (0.75–2.98) |
0.87 |
| SULT1A1 His carriers |
22/62 |
0.86 (0.45–1.64) |
27/36 |
2.58 (1.27–5.25) |
0.03 |
| EPHX1 exon 3 His carriers |
28/62 |
1.31 (0.70–2.46) |
28/56 |
1.12 (0.57–2.22) |
0.69 |
| EPHX4 exon 4 Arg carriers |
21/63 |
0.84 (0.44–1.60) |
16/38 |
0.89 (0.43–1.85) |
0.85 |
|
|
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| Never-drinkers (32 cases, 121 controls) |
Ever-drinkers (73 cases, 133 controls) |
p for heterogeneity |
|||
|
|
|||||
| cases/controls |
OR (95% CI) |
cases/controls |
OR (95% CI) |
||
|
|
|||||
| GSTM1 null |
16/64 |
0.95 (0.43–2.10) |
43/70 |
1.23 (0.69–2.20) |
0.55 |
| GSTT1 null |
13/24 |
3.15 (1.32–7.47) |
26/33 |
1.72 (0.92–3.22) |
0.27 |
| CYP2E1*5 |
0/10 |
- |
5/10 |
0.86 (0.28–2.68) |
- |
| CYP2E1*5A or *6 |
1/19 |
0.18 (0.22–1.46) |
14/8 |
3.70 (1.45–9.37) |
0.001 |
| SULT1A1 His carriers |
16/51 |
1.42 (0.63–3.17) |
33/47 |
1.56 (0.86–2.82) |
0.98 |
|
* OR adjusted for age and gender † Reference groups are the homozygous wild genotypes for each gene ‡ Reference group is fast acetylators (homo-heterozygous for the wild-type allele) | |||||
Boccia et al. BMC Cancer 2007 7:206 doi:10.1186/1471-2407-7-206 |
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