Table 3 |
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Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment |
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Clinical, histologic, and image analysis factors by assessment |
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Field 1 |
Field 2 |
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Factorsa |
P-value |
Factorsa |
P-value |
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Assessment 1 |
Assessment 6 |
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Densitometry (Minimum density) |
0.001 |
Texture (Difference entropy) |
<0.001 |
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Texture (Histogram mean) |
0.02 |
Morphometry (Ellipse major axis) |
<0.001 |
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Texture (Angular second moment) |
0.001 |
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Assessment 2 |
Assessment 7 |
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Texture (Difference entropy) |
0.01 |
Densitometry (Mean density) |
0.001 |
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Morphometry (Ellipse minor axis) |
0.03 |
Texture (Difference entropy) |
0.001 |
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Texture (Diagonal moment) |
0.04 |
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Assessment 3 |
Assessment 8 |
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Texture (Difference entropy) |
0.01 |
Densitometry (Ellipse minor axis) |
0.01 |
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Densitometry (Maximum density) |
0.003 |
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Morphometry (Shape form factor) |
0.04 |
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Assessment 4 |
Assessment 9 |
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Texture (Sum variance) |
0.003 |
Texture (Difference entropy) |
<0.001 |
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Texture (Difference entropy) |
<0.001 |
Texture (Contrast) |
<0.001 |
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Texture (Second diagonal moment) |
<0.001 |
Morphometry (Ellipse major axis) |
0.001 |
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Nuclear grade |
0.001 |
Age |
0.02 |
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Morphometry (Ellipse major axis) |
0.01 |
Densitometry (Range density) |
0.03 |
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Assessment 5 |
10 |
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Densitometry (Minimum density) |
<0.001 |
Morphometry (Shape form factor) |
0.001 |
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Measured margin |
<0.001 |
Texture (Histogram mean) |
0.02 |
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Texture (Variance) |
<0.001 |
Texture (Difference entropy) |
0.01 |
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Texture (Histogram Mean) |
<0.001 |
Measured margin |
0.05 |
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Texture (Contrast) |
0.002 |
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Field 1 Overall |
Field 2 Overall |
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Assessment 11 |
Assessment 12 |
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Densitometry (Minimum density) |
0.005 |
Texture (Difference entropy) |
<0.001 |
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Texture (Difference entropy) |
0.01 |
Discriminant classification function |
<0.001 |
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Texture (Diagonal moment) |
0.04 |
Parenchymal involvement |
0.001 |
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Both Fields Overall – Assessment 13 |
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Texture (Difference entropy) |
p < 0.001 |
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Texture (Contrast) |
p < 0.001 |
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Texture (Peak transition probability) |
p = 0.01 |
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Densitometry (Range density) |
p = 0.004 |
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Measured margin |
p = 0.05 |
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a Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the step-wise forward Cox regression models. |
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Chapman et al. BMC Cancer 2007 7:174 doi:10.1186/1471-2407-7-174 |
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