Table 3 

Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment 

Clinical, histologic, and image analysis factors by assessment 



Field 1 
Field 2 



Factors^{a} 
Pvalue 
Factors^{a} 
Pvalue 


Assessment 1 
Assessment 6 

Densitometry (Minimum density) 
0.001 
Texture (Difference entropy) 
<0.001 
Texture (Histogram mean) 
0.02 
Morphometry (Ellipse major axis) 
<0.001 
Texture (Angular second moment) 
0.001 



Assessment 2 
Assessment 7 

Texture (Difference entropy) 
0.01 
Densitometry (Mean density) 
0.001 
Morphometry (Ellipse minor axis) 
0.03 
Texture (Difference entropy) 
0.001 
Texture (Diagonal moment) 
0.04 



Assessment 3 
Assessment 8 

Texture (Difference entropy) 
0.01 
Densitometry (Ellipse minor axis) 
0.01 
Densitometry (Maximum density) 
0.003 

Morphometry (Shape form factor) 
0.04 



Assessment 4 
Assessment 9 

Texture (Sum variance) 
0.003 
Texture (Difference entropy) 
<0.001 
Texture (Difference entropy) 
<0.001 
Texture (Contrast) 
<0.001 
Texture (Second diagonal moment) 
<0.001 
Morphometry (Ellipse major axis) 
0.001 
Nuclear grade 
0.001 
Age 
0.02 
Morphometry (Ellipse major axis) 
0.01 
Densitometry (Range density) 
0.03 


Assessment 5 
10 

Densitometry (Minimum density) 
<0.001 
Morphometry (Shape form factor) 
0.001 
Measured margin 
<0.001 
Texture (Histogram mean) 
0.02 
Texture (Variance) 
<0.001 
Texture (Difference entropy) 
0.01 
Texture (Histogram Mean) 
<0.001 
Measured margin 
0.05 
Texture (Contrast) 
0.002 



Field 1 Overall 
Field 2 Overall 

Assessment 11 
Assessment 12 



Densitometry (Minimum density) 
0.005 
Texture (Difference entropy) 
<0.001 
Texture (Difference entropy) 
0.01 
Discriminant classification function 
<0.001 
Texture (Diagonal moment) 
0.04 
Parenchymal involvement 
0.001 
Both Fields Overall – Assessment 13 

Texture (Difference entropy) 
p < 0.001 

Texture (Contrast) 
p < 0.001 

Texture (Peak transition probability) 
p = 0.01 

Densitometry (Range density) 
p = 0.004 

Measured margin 
p = 0.05 



^{a }Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the stepwise forward Cox regression models. 

Chapman et al. BMC Cancer 2007 7:174 doi:10.1186/147124077174 