Table 3

Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment

Clinical, histologic, and image analysis factors by assessment


Field 1

Field 2


Factorsa

P-value

Factorsa

P-value


Assessment 1

Assessment 6

Densitometry (Minimum density)

0.001

Texture (Difference entropy)

<0.001

Texture (Histogram mean)

0.02

Morphometry (Ellipse major axis)

<0.001

Texture (Angular second moment)

0.001


Assessment 2

Assessment 7

Texture (Difference entropy)

0.01

Densitometry (Mean density)

0.001

Morphometry (Ellipse minor axis)

0.03

Texture (Difference entropy)

0.001

Texture (Diagonal moment)

0.04


Assessment 3

Assessment 8

Texture (Difference entropy)

0.01

Densitometry (Ellipse minor axis)

0.01

Densitometry (Maximum density)

0.003

Morphometry (Shape form factor)

0.04


Assessment 4

Assessment 9

Texture (Sum variance)

0.003

Texture (Difference entropy)

<0.001

Texture (Difference entropy)

<0.001

Texture (Contrast)

<0.001

Texture (Second diagonal moment)

<0.001

Morphometry (Ellipse major axis)

0.001

Nuclear grade

0.001

Age

0.02

Morphometry (Ellipse major axis)

0.01

Densitometry (Range density)

0.03


Assessment 5

10

Densitometry (Minimum density)

<0.001

Morphometry (Shape form factor)

0.001

Measured margin

<0.001

Texture (Histogram mean)

0.02

Texture (Variance)

<0.001

Texture (Difference entropy)

0.01

Texture (Histogram Mean)

<0.001

Measured margin

0.05

Texture (Contrast)

0.002


Field 1 Overall

Field 2 Overall

Assessment 11

Assessment 12


Densitometry (Minimum density)

0.005

Texture (Difference entropy)

<0.001

Texture (Difference entropy)

0.01

Discriminant classification function

<0.001

Texture (Diagonal moment)

0.04

Parenchymal involvement

0.001

Both Fields Overall – Assessment 13

Texture (Difference entropy)

p < 0.001

Texture (Contrast)

p < 0.001

Texture (Peak transition probability)

p = 0.01

Densitometry (Range density)

p = 0.004

Measured margin

p = 0.05


a Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the step-wise forward Cox regression models.

Chapman et al. BMC Cancer 2007 7:174   doi:10.1186/1471-2407-7-174

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