Table 4 |
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|
EGFR and HER2 copy number alterations |
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|
# |
Sex |
Ethnicity |
Smoking Status |
Histology |
Source Tissue |
Block Type1 |
Response2 |
EGFR Mutation |
EGFR/CEP7 |
HER2/CEP17 |
EGFR Stratification3 |
HER2 Stratification3 |
|
|
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|
9 |
F |
Asian |
N |
adeno. |
Cerebellum |
Tissue Block |
SD |
Not Sequenced |
2.1 |
1.9 |
High Poly. |
Low Poly. |
|
11 |
F |
Asian |
Unk. |
adeno. |
Lung |
Tissue Block |
PR |
Exon 19 Del*, Exon 20 V774L |
2.7 |
1.5 |
High Poly. |
High Trisomy |
|
27 |
F |
Caucasian |
Y |
SCC |
Lung |
Tissue Block |
PD |
None |
2.1 |
1.5 |
High Poly. |
Low Poly. |
|
34 |
M |
Caucasian |
Y |
SCC |
Lung |
Tissue Block |
SD |
None |
17.3 |
2.6 |
Gene Amp. |
High Poly. |
|
36 |
M |
Asian |
Y |
adeno. |
Pleura |
Tissue Block |
SD |
None |
2.0 |
2.0 |
Low Poly. |
Low Poly. |
|
40 |
M |
Caucasian |
Y |
adeno. |
Pleura |
Cell Block |
SD |
None |
3.1 |
1.4 |
High Poly. |
Low Poly. |
|
42 |
M |
Caucasian |
Y |
adeno. |
Lymph Node |
Tissue Block |
Unk. |
None |
2.1 |
2.3 |
Low Poly. |
High Poly. |
|
43 |
F |
Caucasian |
Y |
adeno. |
Lymph Node |
Tissue Block |
PD |
None |
2.7 |
0.9 |
High Poly. |
Low Trisomy |
|
44 |
F |
Asian |
N |
adeno. |
Pleura |
Tissue Block |
PR |
Exon 20 S768I, Exon 20 L815L |
1.9 |
2.9 |
Low Poly. |
High Poly. |
|
56 |
M |
Caucasian |
Y |
adeno. |
Lung |
Tissue Block |
Unk. |
None |
1.5 |
2.0 |
High Trisomy |
Low Poly. |
|
57 |
M |
Caucasian |
Y |
adeno. |
Lymph Node |
Tissue Block |
SD |
None |
1.6 |
2.2 |
Low Poly. |
High Poly. |
|
64 |
F |
Caucasian |
Y |
|||||||||
|
Pre Rx: |
adeno. |
Lymph Node |
Tissue Block |
- |
None |
1.0 |
1.2 |
Low Trisomy |
High Trisomy |
|||
|
Post Rx: |
adeno. |
Pericaridium |
Tissue Block |
SD |
None |
2.2 |
1.3 |
Low Poly. |
Low Trisomy |
|||
|
66 |
F |
Asian |
N |
adeno. |
Lung |
Tissue Block |
PR |
Exon 19 Del* |
2.9 |
1.2 |
High Poly. |
Low Trisomy |
|
|
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|
Patient data provided for samples displaying increased EGFR or HER2 copy number (Probe/CEP ratio > 2.0) or identified as FISH+ (High Polysomy or Gene Amplification) * = no mutations detected in normal tissue remaining after microdissection 1 = source of patient material (Tissue Block = microdissected formalin-fixed paraffin-embedded tissue block; Cell Block = whole section or microdissected formalin-fixed paraffin-embedded cell block; Cytology = scraped cytology slide) 2 = response as measured radiographically and defined by SWOG modification of the WHO criteria [20]. PD = progressive disease, SD = stable disease, PR = partial response, Unk. = Unknown 3 = Copy number stratification as proposed by Cappuzzo et al [13]. (Disomy = < 2 copies in > 90% of cells, Low Trisomy = ≤2 copies in ≥40% of cells, 3 copies in 10–40% of cells, ≥4 copies in < 10% of cells, High Trisomy = ≤2 copies in ≥40% of cells, 3 copes in ≥40% of cells, ≥4 copes in < 10% of cells, Low Polysomy: ≥4 copies in 10–40% of cells, High Polysomy = ≥4 copies in 40% of cells, Gene Amplification = ≥15 copies in ≥10% of cells) |
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|
Pugh et al. BMC Cancer 2007 7:128 doi:10.1186/1471-2407-7-128 |
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