EGFR expression is associated with nuclear but not cytoplasmic FABP7 immunoreactivity. In one region of a representative GBM specimen, the cytoplasm of neoplastic gemistocytes had pronounced FABP7 immunoreactivity but the nuclei of the same cells were negative (A). In an adjacent section of the same specimen only minimal EGFR staining was seen in the same population of tumor cells (B). In another region of the same specimen, all nuclei of neoplastic astrocytes were marked by FABP7 staining (C), and EGFR expression was also prominent in these cells (D). The scale of photomicrographs is the same as in Figure 1 A.
Liang et al. BMC Cancer 2006 6:97 doi:10.1186/1471-2407-6-97