Signaling pathway and E2F responsive genes associated with numbers of copy number transitions and amplifications. The receptor signaling cascade impinging on Rb includes a number of up-stream genes that are frequently altered in cancers and result in deregulation of the E2F family of transcription factors through inhibition or loss of Rb function. Here, we show genes enriched for association with numbers of copy number transitions (FDR < 0.05). Genes, which have been identified as E2F targets (asterisk) and/or are correlated with E2F1 expression levels (|Pearson correlation| > 0.3) are shown in the top box. Genes which showed less correlation with E2F1 are shown in the bottom box. Genes also associated with numbers of amplifications (FDR < 0.05) are highlighted in yellow. Four additional genes associated with amplifications (FDR < 0.05) are ASCIZ, MSH5, RAE1 and TDG. Red, increased expression. Blue, decreased expression.
Fridlyand et al. BMC Cancer 2006 6:96 doi:10.1186/1471-2407-6-96