Overview of most frequent DNA amplifications on chromosomes 8, 11, 17 and 20 in 62 breast tumors determined by genome-wide array CGH. A. Heat map depiction of aberrations on chromosomes 8, 11, 17 and 20 and typical chromosome copy number profiles showing amplifications of 8p (including FGFR1), 11q13 (including CCND1), 17q (ERBB2) and regions on 20q (including ZNF217). Note that the chromosome 11 copy number profiles vary depending on whether amplification of chromosome 8 is also present. In both cases copy number losses distal to the amplicon are observed, however in the absence of chromosome 8 amplification (right), the region of loss extends distally from the amplified region, whereas, when chromosome 8 was amplified (left), the copy number loss includes regions proximal as well as distal to CCND1. B. For each tumor, the numbers of copy number transitions is compared to the number of chromosome arms with at least one amplification.
Fridlyand et al. BMC Cancer 2006 6:96 doi:10.1186/1471-2407-6-96