  Research articleAlternating current electrical stimulation enhanced chemotherapy: a novel strategy to bypass multidrug resistance in tumor cellsDamir Janigro1,3,4 1 Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106 –, USA 2 Department of Molecular Genetics, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106 –, USA 3 Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106 –, USA 4 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106 –, USA
BMC Cancer 2006, 6:72doi:10.1186/1471-2407-6-72
Additional filesAdditional File 1: Very low intensity alternating current decreases cell proliferation. Electric fields impact cellular functions by activation of ion channels or by interfering with cell membrane integrity. Ion channels can regulate cell cycle and play a role in tumorigenesis. In the absence of thermal influences, low-frequency, low-intensity, alternating current (AC) directly affects cell proliferation without a significant deleterious contribution to cell survival. However, to be effective, exposure to AC stimulation also requires a permissive role for GIRK2 (or KIR3.2) potassium channels. Format: PDF Size: 561KB Download file This file can be viewed with: Adobe Acrobat Reader |
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