Figure 2.

Incision of uracil by AG11134 nuclear extracts. The experiment was performed as in Fig. 1 except that uracil-containing oligonucleotide was used instead of 8-OH-Gua-containing oligonucleotide. Panel A, incision of uracil by AG11134 nuclear extracts, B, incision of uracil by HCC1937 nuclear extracts, C, incision of uracil by MCF-7 nuclear extracts and D, quantified incision of uracil by AG11134, HCC1937 and MCF-7 nuclear extracts. The results represent three independent experiments.