Table 2

Summary of results for 30 lung cancers screened for mutations in KRAS

Patient

Histology

HRM

Sequencing

AA change

EGFR sequencing

1

Adenocarcinoma

wt

wt

-

wt

2

Adenocarcinoma

wt

wt

-

wt

3

Adenocarcinoma

mut

35G > T

G12V

wt

4

Adenocarcinoma

mut

34G > T

G12C

wt

5

Adenocarcinoma

wt

wt

-

wt

6

Adenocarcinoma

mut

35G > A

G12D

wt

7

Adenocarcinoma

wt

wt

-

wt

8

Adenocarcinoma

wt

wt

-

wt

9

Adenocarcinoma

wt

wt

-

exon 19 del

10

Adenocarcinoma

wt

wt

-

exon 19 del

11

Adenocarcinoma

wt

wt

-

wt

12

Adenocarcinoma

wt

wt

-

wt

13

Adenocarcinoma

mut

35G > T

G12V

wt

14

Adenocarcinoma

mut

34G > T

G12C

wt

15

Adenocarcinoma

wt

wt

-

wt

16

Adenocarcinoma

wt

wt

-

wt

17

Adenocarcinoma

wt

wt

-

exon 19 del

18

Adenocarcinoma

mut

38G > A

G13D

wt

19

Adenocarcinoma

wt

wt

-

wt

20

Adenocarcinoma

wt

wt

-

wt

21

Adenocarcinoma

wt

wt

-

wt

22

Adenocarcinoma

mut

35G > T

G12V

wt

23

Large cell

wt

wt

-

Not done

24

Large cell

wt

wt

-

Not done

25

Large cell

mut

35G > C

G12A

Not done

26

Large cell

wt

wt

-

Not done

27

Large cell

wt

wt

-

Not done

28

Large cell

wt

wt

-

Not done

29

Large cell

mut

35G > T

G12V

Not done

30

Large cell

wt

wt

-

Not done

HRM – high resolution melting, wt – wild-type, mut – mutant, AA change – amino acid change, exon 19 del – EGFR Exon 19 deletion

Krypuy et al. BMC Cancer 2006 6:295   doi:10.1186/1471-2407-6-295