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Open Access Highly Accessed Research article

Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study

Barbara Burwinkel12, Kalai S Shanmugam12, Kari Hemminki23, Alfons Meindl4, Rita K Schmutzler56, Christian Sutter7, Barbara Wappenschmidt56, Marion Kiechle4, Claus R Bartram7 and Bernd Frank12*

Author Affiliations

1 Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany

2 Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany

3 Center for Family Medicine, Karolinska Institute, Huddinge, Sweden

4 Department of Gynaecology and Obstetrics, Klinikum rechts der Isar at the Technical University, Munich, Germany

5 Division of Molecular Gynaeco-Oncology, Department of Gynaecology and Obstetrics, Clinical Center University of Cologne, Germany

6 Center of Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Germany

7 Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

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BMC Cancer 2006, 6:268  doi:10.1186/1471-2407-6-268

Published: 17 November 2006

Abstract

Background

The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes.

Methods

We investigated the effect of the TCF7L2 rs12255372 variant on familial breast cancer (BC) risk by means of TaqMan allelic discrimination, analyzing BRCA1/2 mutation-negative index patients of 592 German BC families and 735 control individuals.

Results

The T allele of rs12255372 showed an association with borderline significance (OR = 1.19, 95% C.I. = 1.01-1.42, P = 0.04), and the Cochran-Armitage test for trend revealed an allele dose-dependent association of rs12255372 with BC risk (Ptrend = 0.04).

Conclusion

Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC.