Table 3

Association between NAT1 and NAT2 and bladder cancer risk among women and men

NHS

HPFS


Genotype

Case, n (%)

Control, n (%)

OR (95% CI)1

OR (95% CI)2

Case, n (%)

Control, n (%)

OR (95% CI)1

OR (95% CI)2


NAT2 genotype

Rapid and intermediate acetylators

20 (31.8)

1007 (37.9)

1.00 ref

1.00 ref

53 (42.7)

463 (38.2)

1.00 ref

1.00 ref

Slow acetylator

43 (68.3)

1645 (62.0)

1.31 (0.77, 2.24)

1.33 (0.77, 2.31)

71 (57.2)

750 (61.8)

0.81 (0.55, 1.19)

0.78 (0.53, 1.15)

Rapid acetylator

2 (3.2)

131 (4.9)

1.00 ref

1.00 ref

5 (3.9)

72 (5.6)

1.00 ref

1.00 ref

Intermediate acetylator

18 (28.6)

876 (33.0)

1.34 (0.31, 5.86)

1.29 (0.29, 5.65)

48 (37.5)

391 (30.3)

1.84 (0.70, 4.83)

1.94 (0.73, 5.12)

Slow acetylator

43 (68.3)

1645 (62.0)

1.70 (0.41, 7.10)

1.67 (0.40, 6.98)

71 (57.3)

750 (61.8)

1.38 (0.53, 3.58)

1.39 (0.53, 3.60)

NAT1 genotype

Any allele

48 (73.9)

139 (67.2)

1.00 ref

1.00 ref

84 (65.6)

179 (65.8)

1.00 ref

1.00 ref

*10 carrier

17 (26.2)

68 (32.9)

0.76 (0.40, 1.42)

0.77 (0.41, 1.44)

44 (34.4)

93 (33.9)

1.06 (0.68, 1.66)

1.07 (0.68, 1.70)

*4/*4

39 (70.9)

116 (65.2)

1.00 ref

1.00 ref

71 (65.7)

149 (64.2)

1.00 ref

1.00 ref

*10/*4 + *10/*10

16 (29.1)

62 (34.8)

0.79 (0.41, 1.54)

0.81 (0.42, 1.57)

37 (34.3)

83 (35.5)

0.98 (0.60, 1.59)

1.00 (0.61, 1.65)


1 unconditional logistic regression adjusted for age and smoking status

2 unconditional logistic regression adjusted for age, smoking status, and packyears of smoking

McGrath et al. BMC Cancer 2006 6:239   doi:10.1186/1471-2407-6-239

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