Table 2

Association between GSTT1 and GSTM1 and bladder cancer risk among women and men

NHS

HPFS

Genotype

Case, n (%)

Control, n (%)

OR (95% CI)¹

OR (95% CI)²

Case, n (%)

Control, n (%)

OR (95% CI)¹

OR (95% CI)²

GSTT1

Present

50 (76.9)

551 (84.8)

1.00 ref

1.00 ref

106 (83.5)

225 (82.1)

1.00 ref

1.00 ref

Null

14 (21.9)

99 (15.2)

1.63 (0.86, 3.07)

1.57 (0.82, 3.02)

21 (16.5)

49 (17.9)

0.85 (0.48, 1.51)

0.79 (0.44, 1.43)

GSTM1

Present

33 (51.6)

308 (47.5)

1.00 ref

1.00 ref

49 (38.6)

131 (47.8)

1.00 ref

1.00 ref

Null

31 (47.7)

340 (52.5)

0.84 (0.50, 1.42)

0.78 (0.46, 1.33)

78 (61.4)

143 (52.2)

1.44 (0.93, 2.22)

1.46 (0.93, 2.27)

Combined genotype

Both present

26 (40.0)

262 (40.4)

1.00 ref

1.00 ref

39 (30.7)

107 (39.1)

1.00 ref

1.00 ref

Either null

31 (48.4)

333 (51.4)

0.92 (0.53, 1.61)

0.91 (0.52, 1.60)

77 (60.6)

142 (51.8)

1.41 (0.89, 2.25)

1.44 (0.89, 2.32)

Both null

7 (10.8)

53 (8.2)

1.40 (0.58, 3.42)

1.19 (0.46, 3.05)

11 (8.7)

25 (9.1)

1.15 (0.52, 2.58)

1.07 (0.47, 2.45)

P = 0.72

P = 0.95

P = 0.32

P = 0.39

¹ unconditional logistic regression adjusted for age and smoking status

² unconditional logistic regression adjusted for age, smoking status, and packyears of smoking

McGrath et al. BMC Cancer 2006 6:239   doi:10.1186/1471-2407-6-239