Table 2

Mean normalized ERCC1, OGG1 and RAI mRNA levels in normal colonic mucosa and lesions.

ERCC1

OGG1

RAI

Mean level × 1000a

Mean level × 1000a

Mean level × 1000a


Type of tissue

Normal

Lesions

Pb

95% CI

Normal

Lesions

Pb

95% CI

Normal

Lesions

Pb

95% CI


All cases combined

0.55

1.8

0.005

(0.4 ;2.2)

0.33

1.83

3*10-5

(0.9 ; 2.1)

0.26

2.0

0.0005

(0.8 ; 2.7)

Adenomasc

Mild/moderate

0.76

2.2

0.151

(-0.9 ; 3.5)

0.44

2.13

0.069

(-0.2 ; 3.6)

0.31

3.1

0.135

(-1.6 ; 6.6)

Severe

0.39

1.5

0.027

(0.15 ; 2.1)

0.35

1.68

0.004

(0.5 ; 2.2)

0.28

1.85

0.0014

(0.4 ; 1.5)

CRC

0.16

1.5

0.109

(-0.4 ; 3.1)

0.24

1.83

0.034

(0.2 ; 3.0)

0.18

1.46

0.09

(-0.3 ; 2.8)


a) Since ERCC1, OGG1 and RAI expression is expressed as a ratio, normalized, to 18S rRNA expression, it is unit-less.

b) Comparison of the expression levels in lesions and normal colonic mucosa from the same persons.

c) The adenomas are divided in groups according to mild/moderate dysplasia or severe dysplasia.

Sæbø et al. BMC Cancer 2006 6:208   doi:10.1186/1471-2407-6-208

Open Data