Table 5

Genotype frequencies of the seven polymorphisms in subgroups of breast cancer and control populations

Subsets

Case/control

Genotype Frequencies (%)

Chi square test for trend (p value)


1:1

1:2

2:2


IL1A +4845 G>T


Overall

Cancers (n = 697)

360 (51.6%)

275 (39.5%)

62 (8.9%)

X2 = 3.71; p = 0.05

Controls (n = 498)

215 (43.2%)

245 (49.2%)

38 (7.6%)

Positive Family History

Cancers (n = 192)

106 (55.2%)

71 (37%)

15 (7.8%)

X2 = 2.74; p = 0.10

Controls (n = 104)

44 (42.3%)

52 (50%)

8 (7.7%)

Negative Family History

Cancers (n = 505)

254 (50.3%)

204 (40.4%)

47 (9.3%)

X2 = 1.47; p = 0.23

Controls (n = 394)

171 (43.4%)

193 (49%)

30 (7.6%)

Young cancers vs. controls

Cancers (n = 113)

55 (48.7%)

43 (38%)

15 (13.3%)

X2 = 0; p = 0.98

Controls (n = 498)

215 (43.2%)

245 (49.2%)

38 (7.6%)


IL1B -511 C>T


Overall

Cancers (n = 703)

339 (48.2%)

294 (41.8%)

70 (10%)

X2 = 0.10; p = 0.75

Controls (n = 489)

232 (47.4%)

206 (42.1%)

51 (10.4%)

Positive Family History

Cancers (n = 195)

96 (49.2%)

85 (43.6%)

14 (7.2%)

X2 = 0.45; p = 0.51

Controls (n = 103)

48 (46.6%)

45 (43.7%)

10 (9.7%)

Negative Family History

Cancers (n = 508)

243 (47.8%)

209 (41.1%)

56 (11%)

X2 = 0.003; p = 0.96

Controls (n = 386)

184 (47.7%)

161 (41.7%)

41 (10.6%)

Young cancers vs. controls

Cancers (n = 115)

55 (47.8%)

49 (42.6%)

11 (9.6%)

X2 = 0.033; p = 0.86

Controls (n = 489)

232 (47.4%)

206 (42.1%)

51 (10.4%)


IL1B +3954 C>T


Overall

Cancers (n = 691)

410 (59.3%)

242 (35%)

39 (5.6%)

X2 = 1.12; p = 0.29

Controls (n = 420)

231 (55%)

167 (39.8%)

22 (5.2%)

Positive Family History

Cancers (n = 193)

129 (66.8%)

55 (28.5%)

9 (4.7%)

X2 = 8.75; p = 0.003*

Controls (n = 91)

43 (47.3%)

41 (45.1%)

7 (7.7%)

Negative Family History

Cancers (n = 498)

281 (56.4%)

187 (37.6%)

30 (6%)

X2 = 0.26; p = 0.61

Controls (n = 329)

188 (57.1%)

126 (38.3%)

15 (4.6%)

Young cancers vs. controls

Cancers (n = 112)

64 (57.1%)

41 (36.6%)

7 (6.3%)

X2 = 0.03; p = 0.86

Controls (n = 420)

231 (55%)

167 (39.8%)

22 (5.2%)


IL1RN +2018 T>C


Overall

Cancers (n = 697)

349 (50.1%)

286 (41%)

62 (8.9%)

X2 = 0.05; p = 0.82

Controls (n = 490)

247 (50.4%)

202 (41.2%)

41 (8.4%)

Positive Family History

Cancers (n = 193)

94 (48.7%)

84 (43.5%)

15 (7.8%)

X2 = 0.074; p = 0.79

Controls (n = 103)

48 (46.6%)

47 (45.6%)

8 (7.8%)

Negative Family History

Cancers (n = 504)

255 (50.6%)

202 (40.1%)

47 (9.3%)

X2 = 0.14; p = 0.71

Controls (n = 387)

199 (51.4%)

155 (40.1%)

33 (8.5%)

Young cancers vs. controls

Cancers (n = 113)

61 (54%)

44 (38.9%)

8 (7.1%)

X2 = 0.53; p = 0.47

Controls (n = 490)

247 (50.4%)

202 (41.2%)

41 (8.4%)


IL4R +1902 A>G


Overall

Cancers (n = 775)

493 (63.6%)

249 (32.1%)

33 (4.3%)

X2 = 2.1; p = 0.15

Controls (n = 767)

451 (58.8%)

288 (37.5%)

28 (3.7%)

Positive Family History

Cancers (n = 212)

133 (62.7%)

70 (33%)

9 (4.2%)

X2 = 0.19; p = 0.66

Controls (n = 168)

98 (58.3%)

66 (39.3%)

4 (2.4%)

Negative Family History

Cancers (n = 563)

360 (63.9%)

179 (31.8%)

24 (4.3%)

X2 = 2.00; p = 0.16

Controls (n = 599)

353 (58.9%)

222 (37.1%)

24 (4.0%)

Young cancers vs. controls

Cancers (n = 122)

85 (69.7%)

36 (29.5%)

1 (0.8%)

X2 = 6.36; p = 0.012*

Controls (n = 767)

451 (58.8%)

288 (37.5%)

28 (3.7%)


IL6 -174 G>C


Overall

Cancers (n = 497)

170 (34.2%)

244 (49.1%)

83 (16.7%)

X2 = 0.05; p = 0.83

Controls (n = 490)

168 (34.3%)

235 (48%)

87 (17.8%)

Positive Family History

Cancers (n = 127)

47 (37%)

55 (43.3%)

25(19.7%)

X2 = 0.20; p = 0.66

Controls (n = 102)

38 (37.3%)

48 (47.1%)

16(15.7%)

Negative Family History

Cancers (n = 370)

123 (33.2%)

189 (51.1%)

58 (15.7%)

X2 = 1.22; p = 0.64

Controls (n = 388)

130 (33.5%)

187 (48.2%)

71 (18.3%)

Young cancers vs. controls

Cancers (n = 85)

36 (42.4%)

31 (36.5%)

18 (21.2%)

X2 = 0.31; p = 0.58

Controls (n = 490)

168 (34.3%)

235 (48%)

87 (17.8%)


IL10 -1082 G>A


Overall

Cancers (n = 497)

121 (24.3%)

253 (50.9%)

123 (24.7%)

X2 = 0.01; p = 0.93

Controls (n = 498)

117 (23.5%)

260 (52.2%)

121 (24.3%)

Positive Family History

Cancers (n = 126)

31 (24.6%)

69 (54.8%)

26 (20.6%)

X2 = 0.39; p = 0.54

Controls (n = 104)

31 (29.8%)

52 (50%)

21 (20.2%)

Negative Family History

Cancers (n = 371)

90 (24.3%)

184 (49.6%)

97 (26.1%)

X2 = 0.11; p = 0.74

Controls (n = 394)

86 (21.8%)

208 (52.8%)

100 (25.4%)

Young cancers vs. controls

Cancers (n = 84)

17 (20.2%)

44 (52.4%)

23 (27.4%)

X2 = 0.60; p = 0.44

Controls (n = 498)

117 (23.5%)

260 (52.2%)

121 (24.3%)


Note: Family history: either first or second degree relative with breast cancer. Young cancer patients: </=50 years of age

Balasubramanian et al. BMC Cancer 2006 6:188   doi:10.1186/1471-2407-6-188

Open Data