Table 4

Observed and Expected genotype frequencies and the HardyWeinberg Equilibrium in the control population

SNP

Controls (n)

Observed Genotype Frequency

Allele Frequency (in %)

Expected Genotype Frequency

Chi-square Goodness of fit test statistic (p value)


1:1

1:2

2:2

1

2

1:1

1:2

2:2

2:2


IL1A +4845

498

215

245

38

67.8

32.2

229

217

52

χ2 = 7.49; p = 0.01

IL1B -511

489

232

206

51

66.5

31.5

230

211

48

χ2 = 0.20; p = 0.66

IL1B +3954

420

231

167

22

74.9

25.1

235

158

27

χ2 = 1.13; p = 0.29

IL1RN +2018

490

247

202

41

71

29

247

202

41

χ2 = 0; p = 0.95

IL4R +1902

767

451

288

28

77.6

22.4

461

267

39

χ2 = 4.45; p = 0.03

IL6 -174

490

168

235

87

58.3

41.7

167

238

85

χ2 = 0.06; p = 0.81

IL10 -1082

498

117

260

121

49.6

50.4

123

249

126

χ2 = 0.85; p = 0.36


Balasubramanian et al. BMC Cancer 2006 6:188   doi:10.1186/1471-2407-6-188

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