Table 10

Studies of the IL6 -174G>C polymorphism in breast cancer.

Reference

Numbers studied

Type of controls

Susceptibility

Severity

Ethnicity


Cancer

Controls


Smith KC et al, 2004 [57]

144

224

Bone marrow and solid organ donors – male and female

No association

No association

mixed

Hefler LA et al, 2005 [58]

269

227

Women visiting outpatient dept for various reasons

OR = 1.5 (1.04–2.3)* for GC vs. GG OR = 2 (1.1–3.6)* for CC vs. GG

No association

Caucasian

Skerrett DL et al, 2005 [59]

88

102

Maternal cord blood samples

No association

No association

mixed

Saha A et al, 2003 [60]

26

95

Unknown

No association

Not studied

Asian Indian

DeMichelle A et al, 2003 [61]

80

0

-

Not studied

C allele associated with 4 year disease free survival (p = 0.02) and overall survival (p = 0.01) in node positive patients

mixed

Iacopetta B et al, 2004 [62]

256

0

-

Not studied

C allele associated with high grade (p = 0.04) and CC genotype associated with poor survival (p = 0.03)

mixed

Our study

497

490

Women with normal mammograms from screening population

No association

No association

British Caucasian


OR: Odds Ratio

Balasubramanian et al. BMC Cancer 2006 6:188   doi:10.1186/1471-2407-6-188

Open Data