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Open Access Highly Accessed Research article

Prognosis of screen-detected breast cancers: results of a population based study

Laura Cortesi1, Vincenzo E Chiuri1, Silvia Ruscelli1, Valeria Bellelli2, Rossella Negri2, Ivan Rashid3, Claudia Cirilli3, Antonella Fracca3, Ennio Gallo2 and Massimo Federico1*

Author Affiliations

1 Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Italy

2 Dipartimento di Diagnostica per Immagini, Università degli Studi di Modena e Reggio Emilia, Italy

3 Registro Tumori di Modena

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BMC Cancer 2006, 6:17  doi:10.1186/1471-2407-6-17

Published: 23 January 2006

Abstract

Background

The reduced mortality rate from breast carcinoma among women offered screening mammography is demonstrated after 15–20 years of follow-up. However, the assessment of 5-year overall and event-free survival could represent an earlier measure of the efficacy of mammography screening program (MSP).

Methods

All cases of breast cancer diagnosed in the Province of Modena between years 1996 and 2000 in women aged 50 to 69 years, were identified through the Modena Cancer Registry (MCR). Stage of disease and treatment information were obtained from clinical records. All the events occurring up to June 30, 2003 were retrieved by experienced monitors. Five-year overall and event-free survival were the principal end-points of the study.

Results

During a 5-year period, 587 primary breast cancers were detected by the MSP and 471 primary breast cancers were diagnosed out of the MSP. The screen-detected breast cancers were smaller, more likely node negative, with low histological grade, low proliferative activity and positive receptors status. Furthermore, the breast cancer diagnosed through the MSP more frequently received a conservative surgery. The 5-year survival rate was 94% in the screen-detected group, versus 84% in the other group (p = 0.0001). The rate of 5-year event-free survival was 89% and 75% for the MSP participants and not participants, respectively (p = 0.0001).

Conclusions

Our data confirm a favourable outcome of screen-detected breast cancers in terms of five-year overall and event-free survival, which reflect the good quality assurance parameters of the MSP. Finally, a cancer registry should be implemented in every area covered by screening programs.