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Open Access Case report

Recurrence in skeletal muscle from squamous cell carcinoma of the uterine cervix: a case report and review of the literature

Gabriella Ferrandina13*, Vanda Salutari1, Antonia Testa1, Gian Franco Zannoni2, Marco Petrillo1 and Giovanni Scambia3

Author Affiliations

1 Gynecologic Oncology Unit, Catholic University, L.go Gemelli 8, 00168, Rome, Italy

2 Institute of Human Pathology, Catholic University, L.go Gemelli 8, 00168, Rome, Italy

3 Department of Oncology, Catholic University, Contrada Tappino, Campobasso, Italy

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BMC Cancer 2006, 6:169  doi:10.1186/1471-2407-6-169

Published: 27 June 2006



The occurrence of skeletal muscle metastases is a very rare event. Only two cases of late skeletal muscle recurrence from cervical cancer have been documented until now.

Case presentation

A 38-year old patient, submitted to radical hysterectomy and pelvic lymphadenectomy for a squamous FIGO stage IB1 cervical carcinoma, presented after 76 months with a palpable, and painless swelling on the left hemithorax. MRI showed a nodule located in the context of the intercostal muscles. Pathology revealed the presence of metastasis of squamous cell carcinoma of similar morphology as the primary. On the basis of FDG-PET findings, which excluded other sites of disease, surgical excision of the lesion was performed. The patient was triaged to chemotherapy plus external radiotherapy.


A case of skeletal muscle recurrence from cervical cancer after a very long interval from primary diagnosis is reported. Muscular pain or weakness, or just a palpable mass in a patient with a history of cancer has always to raise the suspicion of muscle metastasis.