|
Results of histomorphometrical analysis of effects of the treatments on LuCaP 23.1 and bone |
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| BV/TV (%) |
TUV/TV (%) |
TB.TH. (μM) |
TB. N. (MM-1) |
TB.SP. (μM) |
OS.S./BS (%) |
OS.TH. (μM) |
OB.PM./BPM. (%) |
N.OC./BS (%) |
|
|
|
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| Control |
23.09 ± 9.34 |
30.62 ± 5.75 |
94.89 ± 31.75 |
6.06 ± 1.41 |
76.87 ± 20.90 |
7.24 ± 1.82 |
4.57 ± 0.29 |
15.97 ± 5.08 |
1.91 ± 0.35 |
| ZOL |
36.51 ± 7.86 |
17.68 ± 6.79a |
145.7 ± 31.64 |
5.08 ± 0.53 |
52.29 ± 13.51 |
3.96 ± 1.87 |
5.27 ± 0.45 |
8.46 ± 1.42a |
0.83 ± 0.46a |
| DOC |
29.46 ± 8.56 |
28.29 ± 11.18 |
81.53 ± 20.45 |
5.61 ± 0.90 |
100.6 ± 24.88 |
6.73 ± 1.84 |
5.21 ± 0.36 |
14.17 ± 4.36 |
1.19 ± 0.61 |
| ZOL + DOC |
40.38 ± 8.73a |
11.13 ± 3.41a,b |
118.5 ± 25.56 |
5.59 ± 0.51 |
61.48 ± 21.83 |
4.77 ± 1.01 |
4.98 ± 0.40 |
11.92 ± 5.90 |
0.77 ± 0.42a |
|
Tumored tibiae were harvested after seven weeks of treatment and embedded in methacrylate. Analysis was performed on Goldner-stained longitudinal sections of tibiae (n = 5 per group). Results are presented as a mean ± SD. a p < 0.5 vs. control group b p = 0.11 group 2 vs. group 4 | |||||||||
Brubaker et al. BMC Cancer 2006 6:15 doi:10.1186/1471-2407-6-15 |
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