Table 1

Tumorigenicity of MPM cell lines after orthotopic and subcutaneous implantation in nude mice.
Cell line
 Histology
 Tumorigenicity
 Implantation method
 Survival(days) (mean ± SD)
 Survival (days) (Min/Max)
IST-Mes2
 Epithelioid
 0/15
 Orthotopic
 -
 -

Epithelioid
 0/15
 Subcutaneous
 -
 -
IST-Mes3
 Biphasic
 15/15
 Orthotopic
 81,5 ± 21,7
 60/122

Biphasic
 15/15
 Subcutaneous
 Sacrificed after 90 days
 -
IST-Mes3/2P
 Biphasic
 15/15
 Orthotopic
 69,6 ± 14,5
 54/89
MM-B1
 Biphasic
 15/15
 Orthotopic
 72,5 ± 6,4
 68/77

Biphasic
 0/15
 Subcutaneous
 -
 -

2 × 106 MPM cells were injected into the pleural cavity of nude mice. The experiment ended when mice were moribund.

Martarelli et al. BMC Cancer 2006 6:130   doi:10.1186/1471-2407-6-130