Table 5

Gene ontology for differentially expressed genes found in Caco-2 cells

Gene Category

Down (genes)

Up (genes)

Combined list Affy probes

EASE score


cell motility

8

1

10

0.0459

cytoplasm organization and biogenesis

8

1

10

0.0459

muscle development

7

1

9

0.0872

morphogenesis

18

7

33

0.0879

development

22

10

43

0.107

cell adhesion

11

3

18

0.112

cell surface receptor linked signal transduction

11

3

18

0.112

organelle organization and biogenesis

6

1

8

0.158

cytoskeleton organization and biogenesis

6

1

8

0.158

cell organization and biogenesis

11

4

19

0.159

organogenesis

16

7

31

0.179

response to stress

8

3

14

0.282

macromolecule biosynthesis

9

4

17

0.331

cell-cell signaling

6

2

10

0.346

signal transduction

19

5

30

0.0118

immune response

9

1

11

0.0233

protein metabolism

15

4

23

0.0235

cellular process

58

34

126

0.0316

defense response

10

2

14

0.0467

transcription\, DNA-dependent

17

10

37

0.358

transcription

17

10

37

0.358

response to biotic stimulus

10

5

20

0.374

nucleobase\, nucleoside\, nucleotide and nucleic acid metabolism

24

16

56

0.434

regulation of transcription\, DNA-dependent

16

10

36

0.442

regulation of transcription

16

10

36

0.442

cell cycle

9

5

19

0.486

nucleotide metabolism

3

2

7

0.835

nuclear division

3

3

9

0.927

mitosis

3

3

9

0.927

mitotic cell cycle

5

3

11

0.691

cytokinesis

2

2

6

0.952


Bold: processes significantly downregulated in NHEK pointing to differentiation

Italicized: specific processes significantly downregulated in Caco-2, pointing to differentiation

Cutoff (EASE score) < 5.00E-01

Cutoff (Number of overlapping genes > 5

Gustafsson et al. BMC Cancer 2005 5:75   doi:10.1186/1471-2407-5-75

Open Data