Matrix view of significantly affected genes. Genes induced/repressed in Caco-2 relative to control and their corresponding expression profiles in NHEK. The color is specific for genelist of affected genes at each time point (unless these are the same genes as from one of the earlier time points). Clearly, the early response at 1 hr is very limited (1,8 genes in Caco-2). There are also almost no genes induced/repressed at 1 hr that continue the trend at later time points – indicating an early transient response. This is markedly different for 12 hr and 24 hr time points that show many common genes. It is also clear that many genes affected by NAC treatment in one cell line don't show the same response in the other cell line.
Gustafsson et al. BMC Cancer 2005 5:75 doi:10.1186/1471-2407-5-75