Table 4

PCNA and apoptosis indices and scores of β-catenin, COX-2, iNOS and nitrotyrosine expression in colonic adenocarcinomas.

Group

Treatment

PCNA-labeling

Apoptotic

Scores for:

no.

index (%)

index (%)

β-Catenin

COX-2

iNOS

Nitrotyrosine

1

AOM/DSS

62.4 ± 13.7^a (30)

4.1 ± 1.9 (30)

3.7 ± 0.7 (30)

3.3 ± 0.7 (30)

3.0 ± 1.0 (30)

3.1 ± 0.8 (30)

2

AOM/DSS/0.04% Nimesulide

38.3 ± 11.1 ^b (6)

11.8 ± 2.9 ^b (6)

2.3 ± 1.0 ^c (6)

1.3 ± 0.5 ^b (6)

1.3 ± 0.5 ^b (6)

1.7 ± 0.5 ^b (6)

3

AOM/DSS/0.05% Troglitazone

43.6 ± 9.0 ^b (9)

10.0 ± 2.4 ^b (9)

2.7 ± 0.7 ^c (9)

1.8 ± 0.8 ^b (9)

1.6 ± 0.5 ^b (9)

1.8 ± 0.6 ^b (9)

4

AOM/DSS/0.05% Bezafibrate

40.5 ± 12.7 ^b (15)

9.7 ± 2.7 ^b (15)

3.0 ± 0.8 (15)

1.8 ± 0.8 ^b (15)

1.6 ± 0.6 ^b (15)

2.2 ± 1.1 ^b (15)

Numbers in parentheses are numbers of lesions examined.

^a : means ± SD.

^b,c Significantly different from group 1 by Student's t-test (^bP < 0.001 and ^cP < 0.05).

Kohno et al. BMC Cancer 2005 5:46   doi:10.1186/1471-2407-5-46