Table 1

Spectrum of PIK3CA mutations in gastric adenocarcinoma

Case

Nucleotide Substitution^a

Amino acid change

Age

Sex

MSI Status^b,c

KRAS Mutation^c

Tumour site

Tumour type

IM^d

28

A3140G

H1047R

37

M

Stable

-

Body

Intestinal

0

100

G1633A

E545K

79

F

High

-

Antrum

Intestinal

1

240

G1624A

E542K

74

M

High

G12D

Antrum

Intestinal

1

310

A3140G

H1047R

72

F

High

G13D

Antrum

Intestinal

1

^aNucleotide change at the position within coding sequence, where position 1 corresponds to the first position of the start codon

^bHigh, high level of MSI; Stable, microsatellite stable

^cAnalysis of KRAS mutations have been performed and reported previously [16]

^dIM, the presence of intestinal metaplasia at tumour edge; 1, present; 0, absent

Li et al. BMC Cancer 2005 5:29   doi:10.1186/1471-2407-5-29