Figure 6.

Detection of tipifarnib-mediated apoptosis in AML cells. (A) Annexin V staining shows that a decrease in cellular proliferation correlates with an increase in apoptosis in the THP1 cell line following treatment with tipifarnib. (B) Apoptosis assay of control and treated cells at day 5. Annexin V stains both apoptotic and necrotic cells, propidium iodide stains necrotic cells only.