Figure 1.

M6P/IGF2R loss of heterozygosity in human head and neck cancer. A single nucleotide polymorphism (c. 1197A>G transition) in exon 9 of the M6P/IGF2R was used to determine loss of heterozygosity in these representative samples [32,33]. (A) Informative head and neck cancer without M6P/IGF2R loss of heterozygosity (i.e. both A and G polymorphisms expressed in tumor). (B) Informative head and neck cancer with M6P/IGF2R loss of heterozygosity (i.e. only G polymorphism expressed in tumor). (C) Non-informative head and neck cancer. Arrow, location of A>G polymorphism; arrowhead, A allele absent.

Jamieson et al. BMC Cancer 2003 3:4   doi:10.1186/1471-2407-3-4
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