Table 3

GO-analysis of 44 signature genes
Biological process GO ID P-value Odds ratio Ex-pected Count Size GO Term Associated gene symbols
GO:0006955 1.4E-12 31.69 1.04 13 620 Immune response HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, CCL18, CXCL11, BNIP3, CD86, CD74
GO:0002376 4.6E-12 26.94 1.47 14 874 Immune system process HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74
GO:0002504 1.8E-08 208.89 0.03 4 18 Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5
GO:0019882 3.5E-08 73.05 0.10 5 58 Antigen processing and presentation HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, CD74
GO:0050896 3.6E-06 8.20 4.13 14 2454 Response to stimulus HLA-DMA, HLA-DPB1, HLA-DRB4, HLA-DRB5, IGHA1, IGLL1, IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3, CD86, CD74
GO:0002828 4.0E-05 327.34 0.01 2 6 Regulation of T-helper 2 type immune response IDO1, CD86
GO:0002682 6.7E-05 14.53 0.45 5 267 Regulation of immune system process HLA-DMA, IDO1, ORM1, CD86, CD74
GO:0042092 1.2E-04 163.62 0.02 2 10 T-helper 2 type immune response IDO1, CD86
GO:0006954 1.4E-04 12.44 0.52 5 310 Inflammatory response IDO1, CXCL9, ORM1, CCL18, CXCL11
GO:0030217 1.5E-04 34.98 0.10 3 62 T cell differentiation HLA-DMA, CD86, CD74
GO:0045058 1.8E-04 130.87 0.02 2 12 T cell selection HLA-DMA, CD74
GO:0006952 2.2E-04 8.75 0.93 6 550 Defense response IDO1, CXCL9, ORM1, CCL18, CXCL11, BNIP3
GO:0045582 3.2E-04 93.45 0.03 2 16 Positive regulation of T cell differentiation HLA-DMA, CD86
GO:0045621 4.1E-04 81.76 0.03 2 18 Positive regulation of lymphocyte differentiation HLA-DMA, CD86
GO:0002460 4.7E-04 23.13 0.16 3 92 Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains HLA-DMA, IDO1, CD86
GO:0030098 4.7E-04 23.13 0.16 3 92 Lymphocyte differentiation HLA-DMA, CD86, CD74
GO:0002250 4.9E-04 22.88 0.16 3 93 Adaptive immune response HLA-DMA, IDO1, CD86
GO:0044419 5.8E-04 12.38 0.40 4 236 Interspecies interaction between organisms HLA-DRB4, MMP1, BNIP3, CD86
GO:0009611 7.2E-04 8.52 0.75 5 445 Response to wounding IDO1, CXCL9, ORM1, CCL18, CXCL11
GO:0002694 8.8E-04 18.52 0.19 3 114 Regulation of leukocyte activation HLA-DMA, CD86, CD74
GO:0050865 1.0E-03 17.56 0.20 3 120 Regulation of cell activation HLA-DMA, CD86, CD74
GO:0045580 1.1E-03 46.67 0.05 2 30 Regulation of T cell differentiation HLA-DMA, CD86
GO:0051704 1.2E-03 7.57 0.84 5 498 Multi-organism process HLA-DRB4, IDO1, MMP1, BNIP3, CD86
GO:0042110 1.4E-03 15.54 0.23 3 135 T cell activation HLA-DMA, CD86, CD74
GO:0050776 1.7E-03 14.54 0.24 3 144 Regulation of immune response HLA-DMA, IDO1, CD86
GO:0002822 1.8E-03 36.28 0.06 2 38 Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IDO1, CD86
GO:0045619 1.8E-03 36.28 0.06 2 38 Regulation of lymphocyte differentiation HLA-DMA, CD86
GO:0002819 1.9E-03 35.29 0.07 2 39 Regulation of adaptive immune response IDO1, CD86
GO:0002521 1.9E-03 13.94 0.25 3 150 Leukocyte differentiation HLA-DMA, CD86, CD74
GO:0002684 1.9E-03 13.94 0.25 3 150 Positive regulation of immune system process HLA-DMA, IDO1, CD86
GO:0006935 2.1E-03 13.57 0.26 3 154 Chemotaxis CXCL9, CCL18, CXCL11
GO:0042330 2.1E-03 13.57 0.26 3 154 Taxis CXCL9, CCL18, CXCL11
GO:0007267 2.3E-03 6.50 0.97 5 576 Cell-cell signaling CXCL9, PCSK1, CCL18, CXCL11, CD86
GO:0050870 3.5E-03 25.58 0.09 2 53 Positive regulation of T cell activation HLA-DMA, CD86
GO:0046649 4.2E-03 10.52 0.33 3 197 Lymphocyte activation HLA-DMA, CD86, CD74
GO:0051251 5.0E-03 21.37 0.11 2 63 Positive regulation of lymphocyte activation HLA-DMA, CD86
GO:0007626 5.5E-03 9.52 0.37 3 217 Locomotory behavior CXCL9, CCL18, CXCL11
GO:0009605 5.6E-03 5.20 1.20 5 710 Response to external stimulus IDO1, CXCL9, ORM1, CCL18, CXCL11
GO:0030097 5.6E-03 9.43 0.37 3 219 Hemopoiesis HLA-DMA, CD86, CD74
GO:0002696 6.3E-03 18.88 0.12 2 71 Positive regulation of leukocyte activation HLA-DMA, CD86
GO:0050867 6.6E-03 18.34 0.12 2 73 Positive regulation of cell activation HLA-DMA, CD86
GO:0045321 6.8E-03 8.77 0.40 3 235 Leukocyte activation HLA-DMA, CD86, CD74
GO:0048534 7.1E-03 8.66 0.40 3 238 Hemopoietic or lymphoid organ development HLA-DMA, CD86, CD74
GO:0048583 7.2E-03 8.62 0.40 3 239 Regulation of response to stimulus HLA-DMA, IDO1, CD86
GO:0050863 8.1E-03 16.47 0.14 2 81 Regulation of T cell activation HLA-DMA, CD86
GO:0002520 8.4E-03 8.13 0.43 3 253 Immune system development HLA-DMA, CD86, CD74

Fehlker et al.

Fehlker et al. BMC Cancer 2014 14:64   doi:10.1186/1471-2407-14-64

Open Data