Open Access Open Badges Case report

A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity

Masataka Matsumoto12*, Takashi Nakayama3, Daiki Inoue2, Kazufumi Takamatsu2, Ryo Itotani2, Manabu Ishitoko2, Shinko Suzuki2, Minoru Sakuramoto2, Yoshiaki Yuba4, Osamu Yoshie5, Masaya Takemura2 and Motonari Fukui2

Author Affiliations

1 Division of Respiratory Medicine, Kita-Harima Medical Center, Ono, Japan

2 Division of Respiratory Medicine, Kitano Hospital, Osaka, Japan

3 Division of Chemotherapy, Kinki University Faculty of Pharmacy, Osaka, Japan

4 Department of Pathology, Kitano Hospital, Osaka, Japan

5 Department of Microbiology, Kinki University School of Medicine, Osaka, Japan

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BMC Cancer 2014, 14:588  doi:10.1186/1471-2407-14-588

Published: 13 August 2014



Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers.

Case presentation

We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow.


18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.

Lung cancer; FDG-PET; G-CSF; IL-6; IL-8; Neutrophilia