A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity
1 Division of Respiratory Medicine, Kita-Harima Medical Center, Ono, Japan
2 Division of Respiratory Medicine, Kitano Hospital, Osaka, Japan
3 Division of Chemotherapy, Kinki University Faculty of Pharmacy, Osaka, Japan
4 Department of Pathology, Kitano Hospital, Osaka, Japan
5 Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
BMC Cancer 2014, 14:588 doi:10.1186/1471-2407-14-588Published: 13 August 2014
Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers.
We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow.
18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.