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Open Access Research article

Real world costs and cost-effectiveness of Rituximab for diffuse large B-cell lymphoma patients: a population-based analysis

Sara Khor1234, Jaclyn Beca123, Murray Krahn113567, David Hodgson11378, Linda Lee9, Michael Crump10, Karen E Bremner6, Jin Luo11, Muhammad Mamdani1127, Chaim M Bell127, Carol Sawka37, Scott Gavura13, Terrence Sullivan1437, Maureen Trudeau15, Stuart Peacock16173 and Jeffrey S Hoch111237*

Author Affiliations

1 Pharmacoeconomics Research Unit, Cancer Care Ontario, Toronto, Canada

2 Centre for Excellence in Economic Analysis Research, St Michael’s Hospital, Canada

3 Canadian Centre for Applied Research in Cancer Control, Toronto, Canada

4 Department of Surgery, Surgical Outcomes Research Center, University of Washington, Seattle, WA, USA

5 Toronto Health Economics and Technology Assessment Collaborative, Toronto, Canada

6 Clinical Decision Making and Health Care, Toronto General Hospital, Toronto, Canada

7 Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada

8 Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada

9 Department of Oncology, Niagara Health System, St Catharines, Canada

10 Division of Medical Oncology & Hematology, Princess Margaret Hospital, Toronto, Canada

11 Institute for Clinical Evaluative Sciences, Toronto, Canada

12 Department of Medicine, Mount Sinai Hospital, Toronto, Canada

13 Provincial Drug Reimbursement Programs, Cancer Care Ontario, Toronto, Canada

14 McGill University, Montreal, Canada

15 Sunnybrook Health Sciences Centre, Toronto, Canada

16 British Columbia Cancer Agency, Vancouver, Canada

17 University of British Columbia, Vancouver, Canada

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BMC Cancer 2014, 14:586  doi:10.1186/1471-2407-14-586

Published: 12 August 2014

Abstract

Background

Current treatment of diffuse-large-B-cell lymphoma (DLBCL) includes rituximab, an expensive drug, combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy. Economic models have predicted rituximab plus CHOP (RCHOP) to be a cost-effective alternative to CHOP alone as first-line treatment of DLBCL, but it remains unclear what its real-world costs and cost-effectiveness are in routine clinical practice.

Methods

We performed a population-based retrospective cohort study from 1997 to 2007, using linked administrative databases in Ontario, Canada, to evaluate the costs and cost-effectiveness of RCHOP compared to CHOP alone. A historical control cohort (n = 1,099) with DLBCL who received CHOP before rituximab approval was hard-matched on age and treatment intensity and then propensity-score matched on sex, comorbidity, and histology to 1,099 RCHOP patients. All costs and outcomes were adjusted for censoring using the inverse probability weighting method. The main outcome measure was incremental cost per life-year gained (LYG).

Results

Rituximab was associated with a life expectancy increase of 3.2 months over 5 years at an additional cost of $16,298, corresponding to an incremental cost-effectiveness ratio of $61,984 (95% CI $34,087‒$135,890) per LYG. The probability of being cost-effective was 90% if the willingness-to-pay threshold was $100,000/LYG. The cost-effectiveness ratio was most favourable for patients less than 60 years old ($31,800/LYG) but increased to $80,600/LYG for patients 60–79 years old and $110,100/LYG for patients ≥80 years old. We found that post-market survival benefits of rituximab are similar to or lower than those reported in clinical trials, while the costs, incremental costs and cost-effectiveness ratios are higher than in published economic models and differ by age.

Conclusions

Our results showed that the addition of rituximab to standard CHOP chemotherapy was associated with improvement in survival but at a higher cost, and was potentially cost-effective by standard thresholds for patients <60 years old. However, cost-effectiveness decreased significantly with age, suggesting that rituximab may be not as economically attractive in the very elderly on average. This has important clinical implications regarding age-related use and funding decisions on this drug.