Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Research article

Oncogenic Fli-1 is a potential prognostic marker for the progression of epithelial ovarian cancer

Wei Song1, Lingyun Hu2, Wei Li1, Guanjun Wang1, Yan Li1, Lei Yan1, Ailing Li3* and Jiuwei Cui1*

Author Affiliations

1 Cancer center, the First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, China

2 Obstetrics and Gynecology, the General Hospital of Chinese People’s Liberation Army, Beijing, China

3 Institute of Basic Medical Sciences, National Center of Biomedical Analysis, 27 Tai-Ping Road, Beijing 100850, China

For all author emails, please log on.

BMC Cancer 2014, 14:424  doi:10.1186/1471-2407-14-424

Published: 12 June 2014



Ovarian cancer is the most lethal gynecologic malignancy, but its etiology remains poorly understood. This study investigated the role of Fli-1 in ovarian carcinogenesis and disease survival.


Fli-1 protein expression was evaluated by immunohistochemistry in 104 primary epithelial ovarian cancer (EOC) patients with known follow-up data and 20 controls. Correlation between Fli-1 expression and clinical characteristics was evaluated with the logistic regression. Kaplan Meier analysis was used to assess the impact of Fli-1 expression on overall survival (OS) and disease-free survival (DFS). Cell proliferation and migration assay were used to explore the function of Fli-1 in ovarian cancer cells.


Fli-1 was expressed in 74% cases and up-regulated in EOC tissues compared with normal control tissues (p< 0.05). The high expression of Fli-1 was significantly associated with advanced tumor stage, positive lymph nodal involvement, and poor OS and DFS (p< 0.05). Further analysis showed Fli-1 is an independent prognostic factor for OS and DFS. Down-regulation of Fli-1 inhibited cell proliferation but did not affect cell migration in SKOV3 cells.


This study revealed that Fli-1 played an essential role in the development and progression of ovarian cancers. Its overexpression is intimately related to malignant phenotypes and poor clinical outcome, suggesting that Fli-1 is a potential prognostic marker and therapeutic molecular target in ovarian cancer.

Epithelial ovarian cancer (EOC); Fli-1; Tumor stage; Overall survival