Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
1 Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USA
2 Department of Radiation Oncology, Lindenhofspital, Bern, Switzerland
3 Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland
4 Department of Radiation Oncology, University of West Virginia, Morgantown, WV, USA
5 Department of Biostatistics, East Carolina University, Greenville, NC, USA
6 Department of Pathology, University of Arizona, Tucson, AZ, USA
7 Department of Pediatry, University of Virginia, Charlottesville, VA, USA
8 Department of Radiation Oncology, Akron City Hospital, Akron, OH, USA
9 Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
BMC Cancer 2014, 14:265 doi:10.1186/1471-2407-14-265Published: 17 April 2014
In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.
A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).
At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.
IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.