Relative expression of MLH1 and MGMT in thyroid cancer samples according to mutational status of BRAF V600E (A), RET/PTC rearrangements (B), samples with IDH1 and NRAS transitions (C) or all samples with point mutations (D). Analyses of BRAF V600E mutations and RET/PTC were only performed for the PTC group, as these alterations are exclusive of this subtype. The negative group comprises only the samples without any of the alterations investigated. The symbols represent the mean, and the lines represent the standard error. The left Y-axis indicates the relative expression values of MLH1, and the right Y-axis indicates the relative expression values of MGMT. The p values are indicated if statistically significant.
Santos et al. BMC Cancer 2013 13:79 doi:10.1186/1471-2407-13-79