Table 1

Characteristics of DCIS by surrogate molecular subtypes according to the St Gallen international expert consensus 2011 (n=458)
Ductal carcinoma in situ characteristics All Luminal A Luminal B/HER2- Luminal B/HER2+ HER2+/ER- Triple negative Unclassified P valueb P valuec
n=458 n=186, (%) n=33, (%) n=74, (%) n=61, (%) n=27, (%) n=77, (%)
Percentage of all n=458 (40.6) (7.2) (16.2) (13.3) (5.9) (16.8)
Percentage of all classified n=381 (48.8) (8.7) (19.4) (16.0) (7.1) -
Age mean, years 58.2 59.6 55.2 55.2 58.4 59.2 58.2
< 50 121(26.4) 48 (25.8) 12 (36.4) 23 (31.1) 14 (23.0) 8 (29.6) 16 (20.8) 0.38 0.42
50- 65 198 (43.2) 77 (41.4) 14 (42.4) 33 (44.6) 30 (49.2) 7 (25.9) 37 (48.0)
> 65 139 (30.3) 61 (32.8) 7 (21.2) 18 (24.3) 17 (27.9) 12 (44.4) 24 (31.2)
Detection mode
Screening 345 (75.5) 134 (72.0) 27 (81.8) 67 (90.5) 44 (72.1) 18 (66.7) 55 (71.4) 0.10 0.16
Clinically 112 (24.5) 51 (27.4) 6 (18.2) 7 (9.5) 17 (27.9) 9 (33.3) 22 (28.6)
Tumor size
Unifocal, mean, mm 16.7 14.9 16.5 16.4 21.8 19.9 16.3 0.93d 0.91d
Multifocal (number) n=54 n=22 n=3 n=11 n=8 n=3 n=7
Histopathological gradea
Grade 1 37 (8.1) 23 (12.4) 1 (3.0) 1 (1.4) 1 (1.6) 1 (3.7) 10 (13.0) <0.01 <0.01
Grade 2 203 (44.6) 121 (65.0) 17 (51.5) 20 (27.0) 6 (9.8) 9 (33.3) 32 (41.6)
Grade 3 215 (47.3) 42 (22.6) 15 (45.5) 53 (71.6) 54 (88.5) 17 (63.0) 35 (44.4)
Type of surgery
Breast Conserving Surgery 359 (78.4) 151 (81.2) 28 (84.8) 57 (77.0) 41 (67.2) 22 (81.5) 60 (77.9) 0.17 0.27
Mastectomy 99 (21.6) 35 (18.8) 5 (15.2) 17 (23.0) 20 (32.8) 5 (18.5) 17 (22.1)
Postoperative radiotherapy
Yes 161 (35.2) 63 (33.9) 17 (51.5) 27 (36.5) 23 (37.7) 9 (33.3) 22 (28.6) 0.42 0.33
No 297 (64.8) 123 (66.1) 16 (48.5) 47 (63.5) 38 (62.3) 18 (66.7) 55 (71.4)

aDCIS were classified according to the European Organization for Research and Treatment of Cancer (EORTC) system.

bP-values were calculated between molecular subgroups by IHC, unclassified lesions were excluded.

cP-values were calculated between molecular subgroups by IHC, unclassified lesions were included.

dChi-square test of categorical size groups (unifocal vs. multifocal).

Zhou et al.

Zhou et al. BMC Cancer 2013 13:512   doi:10.1186/1471-2407-13-512

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