Table 1

Baseline characteristics
Variables AFP P value DCP P value
All patients AFP responder AFP non-responder DCP responder DCP non-responder
(n = 115) (n = 91, 79.1%) (n = 24, 20.9%) (n = 77, 66.9%) (n = 38, 33.1%)
Age, years 59 (37 - 78) 59 (37 - 78) 59 (39 - 75) 0.783 59 (37 - 78) 59.9 (40 - 77) 0.661
Male 81 (70.4) 63 (69.2) 18 (75.0) 0.802 53 (68.8) 28 (73.7) 0.668
Etiology
HBV/ HCV/ Others 80 (69.5)/ 18 (15.7)/ 17 (14.8) 63 (69.2)/ 15 (16.5) /13 (14.3) 17 (70.8)/ 3 (12.5)/ 4 (16.7) 0.883 53 (68.8)/ 13 (16.9)/ 11 (14.3) 27 (71.0)/ 5 (13.2)/ 6 (15.8) 0.908
Child-Pugh, A vs. B 108 (93.9)/ 7 (6.1) 89 (97.8)/ 2 (2.2) 19 (79.2)/ 5 (20.8) 0.004 74 (96.1) / 3 (3.9) 34 (89.5)/ 4(10.5) 0.217
Liver cirrhosis 72 (62.6)/ 43 (37.4) 56 (61.5)/ 35 (38.5) 16 (66.7)/ 8(33.3) 0.813 46 (59.7) / 31 (40.3) 26 (68.4)/ 12(31.6) 0.417
Biochemical Variables
Platelet, 103/uL 127 (38 - 414) 134 (38 - 332) 108 (64 - 414) 0.585 123 (38 - 332) 133.5 (60-414) 0.467
ALT, IU/L 38 (12 - 315) 39 (12 - 315) 38 (18 - 116) 0.088 39 (12 - 257) 37 (18 - 315) 0.561
Bilirubin, mg/dL 0.7 (0.2 - 13.4) 0.7 (0.2 - 3.0) 0.6 (0.3 - 13.4) 0.405 0.7 (0.2 - 3.0) 0.6 (0.2-13.4) 0.462
AFP, ng/mL 296.7 (24.23 - 83000) 320.95 (24.23 - 50000) 142.96 (26 - 83000) 0.496 320.95 (24.23 - 83000) 280.08 (25.22 - 50000) 0.774
DCP, mAU/mL 231 (20 - 2000) 231 (20 - 2000) 228.5 (23 - 2000) 0.304 276 (20 - 2000) 62.5 (20 - 2000) 0.464
Number of tumora
1/ 2/ 3/ >4 60 (52.2)/ 18 (15.7)/ 9 (7.8)/ 28 (24.3) 13 (54.2)/ 5 (20.8)/ 2 (8.3)/ 4 (16.7) 47 (51,6)/ 13 (14.3)/ 7 (7.7)/ 24 (26.4) 0.732 35(45.4)/ 13 (16.9)/ 6 (7.8)/ 23 (29.9) 25 (65,8)/ 5 (13.2)/ 3(8.0)/ 5(13.2) 0.160
Size of tumor, mmb 47 (10 - 160) 47 (10 - 160) 45.5 (10 - 151) 0.531 49 (10 - 160) 36 (10 - 160) 0.473
BCLC stage
A/ B/ C 62 (53.9)/ 49 (42.6)/ 4 (3.5) 47 (51.6)/ 40 (44.0)/ 4 (4.4) 15 (62.5)/ 9 (37.5)/ 0 (0.0) 0.484 40 (51.9)/ 36 (46.8)/ 1 (1.3) 22 (57.9)/ 13 (34.2)/ 3 (7.9) 0.117
TNM stage of LCSGJ
I/ II/ III/ IVa 21 (18.3)/ 40 (34.8)/ 19 (20.9)/ 29 (31.9)/ 2 (8.3)/ 11 (45.8)/ 0.412 9 (11.7)/ 31 (40.3)/ 12 (31.6)/ 9 (23.7)/ 0.027
42 (36.5)/ 12 (10.4) 34 (37.4)/ 9 (9.9) 8 (33.3)/ 3 (1.5) 27 (35.1)/ 10 (13.0) 15 (39.5)/ 2 (5.3)

Variables are expressed as n (%) or median (range).

anumber of measurable lesion, btotal size of measurable lesion.

AFP, alpha-fetoprotein; DCP, des gamma carboxy prothrombin; HBV, hepatitis B-virus; HCV, hepatitis C-virus; ALT, alanine aminotransferase; BCLC, Barcelona Clinic Liver Cancer; TNM, Tumor-Node-Metastasis; LCSGJ, Liver Cancer Study Group of Japan.

Lee et al.

Lee et al. BMC Cancer 2013 13:5   doi:10.1186/1471-2407-13-5

Open Data