Histological section of a Mucin Depleted Focus (MDF) processed by immunohistochemistry with the LGR-5 antibody. Panel A: Low power magnification of a MDF (red inset) with its surrounding normal mucosa (original magnification 40x). Panel B: higher magnification of the MDF (red inset in panel A) in which an over-expression of LGR-5 is observed. Panel C: higher magnification of the normal mucosa (green inset of panel A). Original magnification 400x.
Femia et al. BMC Cancer 2013 13:48 doi:10.1186/1471-2407-13-48