Table 4

Association of allele and genotype frequencies within selected breast cancer subgroups
SNP Alleles Genotypes
OPG rs2073618 G C GG CG CC
 Invasive tumors 316 (57.5%) 234 (42.5%) 86 (31.3%) 144 (52.4%) 45 (16.4%)
 Non-invasive tumors 22 (39.3%) 34 (60.7%) 6 (21.4%) 10 (35.7%) 12 (42.9%)
 OR (95%CI) p-value* 2.088 (1.189-3.663) p=0.011 p=0.006
RANK rs35211496 T C TT TC CC
 right breasta 62 (25.2%) 184 (74.8%) 9 (7.3%) 44 (35.8%) 70 (56.9)
 left breasta 53 (15.3%) 293 (84.7%) 3 (1.7%) 47 (27.2%) 123 (71.1%)
 OR (95%CI) p-value* 1.863 (1.236-2.808) p=0.003 p=0.009
RANKL rs9533156 C T CC CT TT
 BMI >/=28 70 (50.7%) 68 (49.3%) 22 (31.9%) 26 (37.7%) 21 (30.4%)
 BMI <28 120 (40%) 180 (60%) 24 (16.0%) 72 (48.0%) 54 (36.0%)
 OR (95%CI) p-value* 1.543 (1.029-2.315) p=0.038 p=0.032
RANKL rs1054016 T G TT TG GG
 BMI >/=28 66 (47.8%) 72 (52.2%) 20 (29.0%) 26 (37.7%) 23 (33.3%)
 BMI <28 108 (36.0%) 192 (64.0%) 19 (12.7%) 70 (46.7%) 61 (40.7%)
 OR (95%CI) p-value* 1.630 (1.083-2.453) p=0.021 p=0.018

BMI = body mass index; CI = confidence intervals; RANK = receptor activator of nuclear factor-κB; RANKL = RANK ligand; OPG = osteoprotegerin; OR = odds ratio; *χ2-tests for 2x2 (alleles) and 2x3 (genotypes) tables, respectively; aExclusion of cases with bilateral tumor involvement.

Data not shown concerning the remaining SNPs stratified into further subgroups according to Table 1.

Ney et al.

Ney et al. BMC Cancer 2013 13:40   doi:10.1186/1471-2407-13-40

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