## Table 4 |
|||||

Association of allele and genotype frequencies within selected breast cancer subgroups |
|||||

SNP |
Alleles |
Genotypes |
|||

OPG rs2073618 |
G |
C |
GG |
CG |
CC |

Invasive tumors | 316 (57.5%) | 234 (42.5%) | 86 (31.3%) | 144 (52.4%) | 45 (16.4%) |

Non-invasive tumors | 22 (39.3%) | 34 (60.7%) | 6 (21.4%) | 10 (35.7%) | 12 (42.9%) |

OR (95%CI) p-value* | 2.088 (1.189-3.663) p=0.011 |
p=0.006 |
|||

RANK rs35211496 |
T |
C |
TT |
TC |
CC |

right breast^{a} |
62 (25.2%) | 184 (74.8%) | 9 (7.3%) | 44 (35.8%) | 70 (56.9) |

left breast^{a} |
53 (15.3%) | 293 (84.7%) | 3 (1.7%) | 47 (27.2%) | 123 (71.1%) |

OR (95%CI) p-value* | 1.863 (1.236-2.808) p=0.003 |
p=0.009 |
|||

RANKL rs9533156 |
C |
T |
CC |
CT |
TT |

BMI >/=28 | 70 (50.7%) | 68 (49.3%) | 22 (31.9%) | 26 (37.7%) | 21 (30.4%) |

BMI <28 | 120 (40%) | 180 (60%) | 24 (16.0%) | 72 (48.0%) | 54 (36.0%) |

OR (95%CI) p-value* | 1.543 (1.029-2.315) p=0.038 |
p=0.032 |
|||

RANKL rs1054016 |
T |
G |
TT |
TG |
GG |

BMI >/=28 | 66 (47.8%) | 72 (52.2%) | 20 (29.0%) | 26 (37.7%) | 23 (33.3%) |

BMI <28 | 108 (36.0%) | 192 (64.0%) | 19 (12.7%) | 70 (46.7%) | 61 (40.7%) |

OR (95%CI) p-value* | 1.630 (1.083-2.453) p=0.021 |
p=0.018 |

BMI = body mass index; CI = confidence intervals; RANK = receptor activator of nuclear
factor-κB; RANKL = RANK ligand; OPG = osteoprotegerin; OR = odds ratio; *χ2-tests
for 2x2 (alleles) and 2x3 (genotypes) tables, respectively; ^{a}Exclusion of cases with bilateral tumor involvement.

Data not shown concerning the remaining SNPs stratified into further subgroups according to Table 1.

Ney * et al.*

Ney * et al.* *BMC Cancer* 2013 **13**:40 doi:10.1186/1471-2407-13-40