Table 3

Association of allele and genotype frequencies of OPG, RANK and RANKL in patients with breast cancer and healthy controls
SNP Alleles / Genotypes Breast cancer Healthy controls OR (95% CI) p-value*
OPG rs3102735 n=614 (%) n=784 (%)
Alleles C 113 (18.4%) 102 (13.0%) 1.508 0.006
T 501 (81.6%) 682 (87.0%) (1.127-2.018)
n=307 (%) n=392 (%)
Genotypes CC 10 (3.3%) 5 (1.3%) 0.019
CT 93 (30.3%) 92 (23.5%)
TT 204 (66.4%) 295 (75.3%)
OPG rs2073618 n=614 (%) n=786 (%)
Alleles C 269 (43.8%) 357 (45.4%) 0.937 0.552
G 345 (56.2%) 429 (54.6%) (0.758-1.159)
n=307 (%) n=393 (%)
Genotypes CC 57 (18.6%) 77 (19.6%) 0.810
CG 155 (50.5%) 203 (51.7%)
GG 95 (30.9%) 113 (29.7%)
RANK rs1805034 n=614 (%) n=790 (%)
Alleles C 291 (47.4%) 362 (45.8%) 1.065 0.590
T 323 (52.6%) 428 (54.2%) (0.862-1.316)
n=307 (%) n=395 (%)
Genotypes CC 73 (23.8%) 78 (19.7%) 0.334
CT 145 (47.2%) 206 (52.2%)
TT 89 (29.0%) 111 (28.1%)
RANK rs35211496 n=614 (%) n=792 (%)
Alleles T 122 (19.9%) 141 (17.8%) 1.145 0.335
C 492 (80.1%) 651 (82.2%) (0.875-1.499)
n=307 (%) n=396 (%)
Genotypes TT 12 (3.9%) 9 (2.3%) 0.423
TC 98 (31.9%) 123 (31.1%)
CC 197 (64.2%) 264 (66.7%)
RANKL rs9533156 n=614 (%) n=788 (%)
Alleles C 280 (45.6%) 369 (46.8%) 0.952 0.666
T 334 (54.4%) 419 (53.2%) (0.770-1.176)
n=307 (%) n=394 (%)
Genotypes CC 68 (22.1%) 82 (20.8%) 0.387
CT 144 (46.9%) 205 (52.0%)
TT 95 (30.9%) 107 (27.2%)
RANKL rs2277438 n=614 (%) n=788 (%)
Alleles G 109 (17.8%) 132 (16.8%) 1.073 0.669
A 505 (82.2%) 656 (83.2%) (0.812-1.418)
n=307 (%) n=394 (%)
Genotypes GG 8 (2.6%) 9 (2.3%) 0.866
GA 93 (30.3%) 114 (28.9%)
AA 206 (67.1%) 271 (68.8%)
RANKL rs1054016 n=614 (%) n=786 (%)
Alleles T 258 (42.0%) 345 (43.9%) 0.927 0.514
G 356 (58.0%) 441 (56.1%) (0.749-1.147)
n=307 (%) n=393 (%)
Genotypes TT 57 (18.6%) 73 (18.6%) 0.543
TG 144 (46.9%) 199 (50.6%)
GG 106 (34.5%) 121 (30.8%)

CI = confidence intervals; RANK = receptor activator of nuclear factor-κB; RANKL = RANK ligand; OPG = osteoprotegerin; OR = odds ratio; *χ2-tests for 2x2 tables (alleles) and for 2x3 tables (genotypes), respectively.

Ney et al.

Ney et al. BMC Cancer 2013 13:40   doi:10.1186/1471-2407-13-40

Open Data