Table 2

Base-case costs estimates ($, year 2012 values) and utilities
Parameter Median Range Description and references
Cost of EGFR genotyping per patient 507.9 381–634.9 Local charge
Cost of gefitinib per 250 mg ($) 77.8 38.9–77.8* Local charge
Cost of follow-up per unit ($) 55.6 41.7–69.4 [34]
Cost of 2nd-line chemotherapy per cycle ($) 2352.7 1921.1–4383.3 Calculation
Cost of palliative care in end-of-life treatment ($) 3664.3 21.4–48750.2 Calculation
Cost of supportive care per cycle ($) 337.5 158.7–793.7 Calculation
Cost of SAEs in platinum-based chemotherapy per cycle ($) 507.4 189.7–825.0 Calculation
Expenditures of SAEs in maintenance treatment per cycle
Cost of SAEs in Gefitinib strategy per cycle ($) Formula# Calculation
Utilities
Utility of PFS 0.65 0.26–0.87 [29]
Utility of OS 0.47 0.19–0.58 [29]

* The range was assumed for a one-way sensitivity analysis.

# Formula: Cost of SAEs in platinum-based chemotherapy per cycle × Cumulative probability of SAEs in maintenance strategy / Cumulative probability of SAEs in platinum-based chemotherapy.

Zhu et al.

Zhu et al. BMC Cancer 2013 13:39   doi:10.1186/1471-2407-13-39

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