Table 3

Molecular fingerprint of LGGs composed by the selected 15 genes
Gene/Locus Description Biological Process
FOXG1 / 14q13 forkhead box G1 GO:0007417 CNS development GO:0022008 neurogenesis
GO:0030900 forebrain development GO:0048699 generation of neurons
GO:0021954 CNS neuron development GO:0021953 CNS neuron differentiation
GO:0048666 neuron development GO:0007423 sensory organ development
GO:0043583 ear development GO:0009953 dorsal/ventral pattern formation
GO:0006355 regulation of transcription, DNA-dependent
GO:0051252 regulation of RNA metabolic process
GO:0045449 regulation of transcription
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0048858 cell projection morphogenesis GO:0032990 cell part morphogenesis
GO:0031175 neuron projection development
GPR17 / 2q21 G protein-coupled receptor 17 GO:0007165 signal trasduction
GO:0007186 G-protein coupled receptor protein signaling pathway
CXCL14 / 5q31 chemokine (C-X-C motif) GO:0006995 immune response GO: 0006935 chemotaxis
ligand 14 GO:0007267 cell-cell signaling GO:0007165 signal trasduction
ARX / Xp21 aristaless related homeobox GO:0007417 CNS development, GO:0022008 neurogenesis
GO:0030900 forebrain development, GO:0048699 generation of neurons
GO:0021954 CNS neuron development, GO:0021987 cerebral cortex development
GO:0021543 pallium development
GO:0006355 regulation of transcription, DNA-dependent
GO:0051252 regulation of RNA metabolic process
GO:0045449 regulation of transcription
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0048858 cell projection morphogenesis
GO:0032990 cell part morphogenesis
GO:0031175 neuron projection development
LHX2 / 9q33q34.1 LIM homeobox 2 GO:0007417 CNS development GO:0022008 neurogenesis
GO:0030900 forebrain development GO:0048699 generation of neurons
GO:0048666 neuron development GO:0009953 dorsal/ventral pattern formation
GO:0006355 regulation of transcription, DNA-dependent
GO:0051252 regulation of RNA metabolic process
GO:0045449 regulation of transcription
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048812 neuron projection morphogenesis
GO:0048858 cell projection morphogenesis
GO:0032990 cell part morphogenesis, GO:0031175 neuron projection development
TIMP4 / 3p25 TIMP metallopeptidase GO:0007417 CNS development GO:0009725 response to hormone stimulus
inhibitor 4 GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine stimulus
APOD / 3q26.2qter apolipoprotein D GO.0006629 lipid metabolic process
PTGD2S / 9q34.2-34.3 prostaglandin D2 synthase GO:0006633 fatty acid biosynthetic process
21 kDa (brain) GO:0006810 transport
SDC3 / 1pter-p22.3 syndecan 3 GO:0007155 cell adhesion
NRXN2 / 11q13 neurexin 2 GO:0007268 synaptic trasmission GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly GO:0007155 cell adhesion
SNX22 / 15q22.31 sorting nexin 22 GO:0007165 signal trasduction GO:0007154 cell comunication
ZFHX4 / 8q21.11 zinc finger homeobox 4 GO:0006355 regulation of transcription, DNA-dependent
GO:0051252 regulation of RNA metabolic process
GO:0045449 regulation of transcription
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid
GO:0015031 protein transport
SPOCK1 / 5q31 testican 1 GO:0007417 CNS development GO:0007165 signal trasduction
GO:0007155 cell adhesion
ABBA1 / 16q22.1 metastasis suppressor 1 like GO:0007165 signal trasduction
FOSB / 19q13.32 FBJ murine osteosarcoma GO:0006355 regulation of transcription, DNA-dependent
viral oncogene homolog B GO:0051252 regulation of RNA metabolic process
GO:0045449 regulation of transcription
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid

Gene annotations and GO Biological Process terms for the minimal list of 15 genes, selected for the biologically validated molecular fingerprint of LGGs related to site of lesion (infratentorial vs supratentorial).

Mascelli et al.

Mascelli et al. BMC Cancer 2013 13:387   doi:10.1186/1471-2407-13-387

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