Table 3

Association between total alcohol and wine intake and histological types* of ovarian carcinoma, OCAC studies
Intake/d Controls N=10,358 High-Grade Serous N=2,580 Mucinous N=245 Endometrioid N=506 Clear Cell N=501 Low-Grade Serous N=198
Co Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) Ca OR (95% CI) P value†
Total alcohol
 None 4,296 1,060 1.0 (Ref) 98 1.0 (Ref) 214 1.0 (Ref) 223 1.0 (Ref) 61 1.0 (Ref)
 Up to 1 drink 3,928 1,029 0.95 (0.84-1.07) 97 1.08 (0.76-1.52) 207 0.97 (0.76-1.23) 188 0.84 (0.66-1.07) 90 0.95 (0.65-1.38)
 1-2 drinks 1,112 282 0.97 (0.83-1.15) 26 1.08 (0.66-1.75) 50 0.96 (0.68-1.36) 53 0.97 (0.69-1.37) 29 1.28 (0.78-2.11)
 2-3 drinks 400 79 0.78 (0.60-1.02) 11 1.36 (0.69-2.67) 23 1.36 (0.85-2.19) 17 0.96 (0.56-1.63) 8 0.98 (0.45-2.13)
 >3 drinks 622 130 0.96 (0.77-1.20) 13 0.98 (0.52-1.82) 12 0.49 (0.27-0.91) 20 0.82 (0.50-1.34) 10 1.12 (0.55-2.29)
P trend 0.31 0.71 0.25 0.50 0.54 0.67
 >2 drinks§ 1,022 209 0.88 (0.74-1.06) 24 1.12 (0.69-1.83) 35 0.85 (0.58-1.26) 37 0.88 (0.60-1.30) 18 1.05 (0.59-1.86)
P trend § 0.24 0.62 0.45 0.52 0.53 0.71
Wine
 None 5,307 1,316 1.0 (Ref) 128 1.0 (Ref) 263 1.0 (Ref) 272 1.0 (Ref) 81 1.0 (Ref)
 Up to 4 oz 3,984 1,022 0.93 (0.83-1.04) 103 1.12 (0.81-1.54) 206 0.96 (0.77-1.21) 195 0.87 (0.69-1.09) 91 0.94 (0.66-1.34)
 4-8 oz 522 129 0.93 (0.75-1.16) 10 1.03 (0.52-2.04) 22 0.98 (0.61-1.58) 24 0.95 (0.60-1.50) 13 1.33 (0.70-2.50)
 >8 oz 545 113 0.86 (0.68-1.09) 4 0.39 (0.14-1.09) 15 0.68 (0.39-1.20) 10 0.43 (0.22-0.83) 13 1.35 (0.71-2.56)
P trend 0.13 0.32 0.29 0.02 0.34 0.09
 >4 oz § 1,067 242 0.89 (0.75-1.06) 14 0.70 (0.39-1.27) 37 0.84 (0.57-1.23) 34 0.70 (0.47-1.03) 26 1.34 (0.81-2.20)
P trend § 0.13 0.61 0.41 0.05 0.44 0.25

Adjusted for age (<40; 40-49; 50-59; 60-69; 70+ years), smoking status (never, former, current), site (AUS, CON, DOV, GER, HAW, HOP, MAL, NCO, NEC, NJO, POL, SON), race/ethnicity (white nonHispanic; white Hispanic; black non Hispanic; Asian; other or unknown); menopausal status (pre/peri-menopausal; postmenopausal, unknown or missing), oral contraceptive use (<6mo, 6-22 mo, 23+ mo, unknown or missing), tubal ligation (yes; no; unknown or missing), endometriosis (yes; no; unknown or missing), hysterectomy (yes; no; unknown or missing), family history of breast or ovarian cancer in first-degree relatives (no; yes; unknown; no daughters or sisters), parity/age at last birth (nulliparous; 1-2 births/age ≤25 yrs at last pregnancy; 3+ births/age ≤25 yrs at last pregnancy; 1-2 births/age >25 years at last pregnancy; 3+ births/age >25 years at last pregnancy; yes if ever pregnant but unknown or missing age at last pregnancy age; no or unknown if ever pregnant and missing age at last pregnancy, interview year (1990-1994; 1995-1999; 2000-2004; 2005-2009; missing), age at menarche (8-10 yrs; 11 yrs; 12 yrs; 13 yrs; 14-21 yrs; <8 or ≥ 22 yrs), body mass index (continuous) and education (less than high school, high school, some college, completed college or university, completed graduate or professional degree, missing).

* Cases restricted to samples with information on grade for serous, mucinous and endometrioid histologic types, and for whom we applied the algorithm to reduce histologic misclassification (see Methods).

P for tumor heterogeneity derived from testing the trend variable for alcohol or wine intake in polytomous regression models with 5 df (see Statistical analysis).

‡ 1 drink = 10 grams ethanol.

§ Risk estimates and P trend values are from models that collapse the two highest intake categories.

Models are also simultaneously adjusted for consumption of beer and liquor intake.

Kelemen et al.

Kelemen et al. BMC Cancer 2013 13:28   doi:10.1186/1471-2407-13-28

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