Figure 4.

MiR-34a reduces cell invasion through Notch signaling. (A) Representative images showing that Notch activation nearly fully nullified the inhibitory effect of miR-34a force-expression on cell invasion. (B) Invasion expressed as relative to the untreated control cells (n = 4). (C) Proliferation of the cells. Parallel experiment demonstrated no significant effect of treatments on proliferation of the transfected cells. (D) uPA and MMP9 mRNA expression in the transfected cells as determined by RT-qPCRs (n = 4) *p < 0.05.