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Open Access Research article

The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients

Hong-Wu Xu12, Yue-Jun Huang23, Ze-Yu Xie1*, Lan Lin1, Yan-Chun Guo1, Ze-Rui Zhuang1, Xin-Peng Lin1, Wen Zhou1, Mu Li1, Hai-Hua Huang4, Xiao-Long Wei5, Kwan Man6 and Guo-Jun Zhang7*

Author Affiliations

1 Department of Neurosurgery, Second Affiliated Hospital of Shantou University Medical College, North Dongxia Rd, Shantou, Guangdong, 515041, China

2 Research Center for Translational Medicine, Second Affiliated Hospital of Shantou University Medical College, North Dongxia Rd, Shantou, Guangdong, 515041, China

3 Department of pediatrics, Second Affiliated Hospital of Shantou University Medical College, North Dongxia Rd, Shantou, Guangdong, 515041, China

4 Department of pathology, Second Affiliated Hospital of Shantou University Medical College, North Dongxia Rd, Shantou, Guangdong, 515041, China

5 Department of pathology, Cancer Hospital of Shantou University Medical College, Raoping Rd, Shantou, Guangdong, 515031, China

6 Department of Surgery and Centre for Cancer Research, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China

7 The Breast Center, Cancer Hospital of Shantou University Medical College, Raoping Rd, Shantou, Guangdong, 515031, China

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BMC Cancer 2013, 13:247  doi:10.1186/1471-2407-13-247

Published: 20 May 2013

Abstract

Background

Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene.

Methods

We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and vascular endothelial growth factor (VEGF) in 88 patients with 41 high-grade gliomas and 47 low-grade gliomas. Intratumoral microvessel density (IMD) was also determined and associated with clinicopathological factors.

Results

Low expression of Cygb was significantly associated with the higher histological grading and tumor recurrence. A significant negative correlation emerged between Cygb expression and PI3K, p-Akt, IL-6, TNFα or VEGF expression. Cygb expression was negatively correlated with IMD. There was a positive correlation between PI3K, p-Akt, IL-6, TNFα and VEGF expression with IMD.High histologic grade, tumor recurrence, decreased Cygb expression, increased PI3K expression, increased p-Akt expression and increased VEGF expression correlated with patients’ overall survival in univariate analysis. However, only histological grading and Cygb expression exhibited a relationship with survival of patients as independent prognostic factors of glioma by multivariate analysis.

Conclusions

Cygb loss may contribute to tumor recurrence and a worse prognosis in gliomas. Cygb may serve as an independent predictive factor for prognosis of glioma patients.

Keywords:
Glioma; Cytoglobin; Phosphatidylinositol-3 kinase; Recurrence; Prognosis