Table 3

Adjusted HRs of all-cause mortality associated with race (black women vs. white women)
White Black Model 1a Model 2a,b
Person-years Death (No.) Person-years Death (No.) HR 95% CI HR 95% CI
All women 6246 155 4471 180 1.65 1.32 to 2.06 1.42 1.13 to 1.78
Subtypes defined by ER/PR/HER2
 TN 1341 50 1381 66 1.25 0.85 to 1.84 1.12 0.76 to 1.66
 Luminal A 3853 75 2235 70 1.75 1.25 to 2.46 1.54 1.09 to 2.18
 Luminal B 643 16 481 16 1.74 0.70 to 4.31 1.07 0.32 to 3.53
 HER2-enriched 408 14 375 28 2.69 1.06 to 6.85 2.41 0.90 to 6.40
Subtypes defined by ER/PR/HER2/p53
 TN/p53- 825 26 664 34 1.45 0.82 to 2.54 1.38 0.77 to 2.49
 TN/p53+ 516 24 717 32 1.04 0.58 to 1.88 1.04 0.57 to 1.89
 Luminal A/p53- 3262 55 1814 52 1.73 1.16 to 2.58 1.62 1.08 to 2.43
 Luminal A/p53+ 591 20 421 18 1.45 0.60 to 3.54 0.99 0.37 to 2.70
Younger women (ages 35–49 yrs) 3066 90 2248 95 1.49 1.10 to 2.01 1.27 0.94 to 1.73
Subtypes defined by ER/PR/HER2
 TN 861 34 785 43 1.36 0.84 to 2.18 1.16 0.71 to 1.89
 Luminal A 1623 36 1069 28 1.33 0.79 to 2.23 1.20 0.71 to 2.03
Subtypes defined by ER/PR/HER2/p53
 TN/p53- 513 18 372 21 1.44 0.72 to 2.87 1.43 0.70 to 2.90
 TN/p53+ 349 16 413 22 1.21 0.60 to 2.47 1.13 0.54 to 2.36
 Luminal A/p53- 1329 28 792 17 1.06 0.56 to 2.01 1.05 0.54 to 2.02
 Luminal A/p53+ 294 8 277 11 1.32 0.32 to 5.42 0.92 0.21 to 4.06
Older women (ages 50–64 yrs) 3181 65 2223 85 1.89 1.36 to 2.62 1.62 1.17 to 2.26
Subtypes defined by ER/PR/HER2
 TN 480 16 596 23 1.04 0.54 to 2.02 1.07 0.55 to 2.11
 Luminal A 2231 39 1167 42 2.21 1.40 to 3.47 1.88 1.18 to 2.99
Subtypes defined by ER/PR/HER2/p53
 TN/p53- 313 8 292 13 1.66 0.61 to 4.54 1.48 0.50 to 4.41
 TN/p53+ 167 8 304 10 0.77 0.27 to 2.20 0.79 0.27 to 2.30
 Luminal A/p53- 1934 27 1022 35 2.49 1.47 to 4.22 2.22 1.30 to 3.79
 Luminal A/p53+ 297 12 144 7 1.54 0.48 to 4.91 1.44 0.25 to 8.11

HRs are from multivariable Cox proportional hazards regression models using age (in days) at diagnosis and at death or end of follow-up as the time scale and stratified by single years of age at diagnosis. aAdjusted for study site. bAdditionally adjusted for tumor stage. Abbreviations: HR, hazard ratio; CI, confidence interval. ER, estrogen receptor; PR, progesterone receptor; HER, human epidermal growth factor receptor; TN, triple negative. Note: TN = ER-/PR-/HER2-, Luminal A = ER+ or PR+ plus HER2-, Luminal B = ER+ or PR+ plus HER2+, HER2-enriched = ER-/PR-/HER2+.

Ma et al.

Ma et al. BMC Cancer 2013 13:225   doi:10.1186/1471-2407-13-225

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