Effects of PDGF-BB and imatinib mesylate on phosphorylation of PDGFRs. PDGFR-β of all six MPNST cell lines was phosphorylated in response to 25 ng/ml of PDGF-BB for 30 min. PDGF-BB stimulation did not induce any phosphorylation of PDGFR-α in all cell lines. Pretreatment with 10 μM imatinib mesylate almost completely suppressed PDGF-BB-induced PDGFR-β phosphorylation in all cell lines.
Ohishi et al. BMC Cancer 2013 13:224 doi:10.1186/1471-2407-13-224