Vaccination study in human FcεRIα transgenic mice. Survival plot of human FcεRIα transgenic mice vaccinated subcutaneously in the left flank with PSA alone (4 μg) or complexed in a 1:1 molar ration to either the anti-PSA IgE or IgG1. Mice were given a booster on day 15, also in the left flank. Two-weeks after the booster on day 40, mice were challenged with 106 murine CT26 cells expressing human PSA (CT26-PSA) subcutaneously in the right flank. Animals admininstered with buffer alone were used as negative controls. The survival plot shown is the combined data from 2 independent experiments with a total of 8 mice per group and was generated in GraphPad Prism.
Daniels-Wells et al. BMC Cancer 2013 13:195 doi:10.1186/1471-2407-13-195