Table 3

Gene names and functions of the 13 genes with mean log2 expression fold changes (A) and six proteins with mean log2 abundance values in controls, FIGO I/II patients, and FIGO III/IV patients (B)
A)
ProbeID Gene symbol Gene name Function FIGO I/IIa FIGO III/IV JAK STAT Inflammatory response
115368 AP2A1 adaptor-related protein complex 2, alpha 1 subunit Clathrin coat assembly Down. FCb: -0.75 Down FC: -0.82
142487 B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypept. 1 Galactosyltransferase Down (FC: -0.81) Down (FC: -0.59) +
157342 C1orf63 chromosome 1 ORF 63 Unknown n.s. FC: +0.003 n.s. FC: +0.19
110071 CCR2 chemokine (C-C motif) receptor 2 Chemokine receptor n.s. FC: +0.72 Up FC: +0.96 + +
119290 CFP complement factor properdin Alternative pathway for complement activation Down FC: -1.06 Down FC: -1.03 +
105743 DIS3 DIS3 mitotic control homolog (S. cerevisiae) RNase, part of the exosome complex n.s. (FC: +0.01) Up (FC: +0.27)
228089 NEAT1 non-protein coding RNA 84 Non-coding RNA n.s. FC: -0.01 n.s. FC: +0.26
182018 NOXA1 NADPH oxidase activator 1 Activates NADPH oxidases n.s. FC: -0.52 Down FC: -0.60
205406 OSM oncostatin M IL-6 family cytokine Down FC: -2.62 Down FC: -2.65 +
161567 PAPOLG poly(A) polymerase gamma Poly(A) polymerase n.s. FC: -0.28 n.s. FC: -0.34
162222 PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285 Nuclear transcriptional coactivator for several nuclear receptors Down FC: -2.24 Down FC: -2.33
109227 ZNF419 zinc finger protein 419 Zinc finger protein n.s. (FC: -.19) n.s. (FC: +0.21)
713562 BC037918 (no ORF in transcript BC037918) Non-coding RNA n.s. FC: +0.06 n.s. FC: +0.52
B)
Protein Control FIGO I/II corr. pc FIGO III/IV corr. pc
log2 MIF 8.86 9.67 0.028 9.25 0.040
log2 prolactin 4.70 6.26 <0.001 6.79 <0.001
log2 CA125 3.83 7.24 <0.001 8.52 <0.001
log2 leptin 3.92 2.78 0.033 2.15 <0.001
log2 osteopontin 3.84 4.59 0.067 5.08 <0.001
log2 IGF2 10.94 9.10 <0.001 9.16 <0.001

aSignificant down- or up-regulation in blood cells of EOC patients compared to healthy blood donors (t-test, corrected for multiple testing; n.s., not significant). bFC are actually log2-FC values.

cCompared to control values.

Pils et al.

Pils et al. BMC Cancer 2013 13:178   doi:10.1186/1471-2407-13-178

Open Data